Anti-proliferation Potential and Content of Fucoidan Extracted From Sporophyll of New Zealand Undaria Pinnatifida

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aut.relation.endpage10
aut.relation.issue9en_NZ
aut.relation.startpage1
aut.relation.volume1en_NZ
aut.researcherHamid, Nazimah
dc.contributor.authorMak, Wen_NZ
dc.contributor.authorWang, SKen_NZ
dc.contributor.authorLiu, Ten_NZ
dc.contributor.authorHamid, Nen_NZ
dc.contributor.authorLu, Jen_NZ
dc.contributor.authorLi, Yen_NZ
dc.contributor.authorWhite, WLen_NZ
dc.date.accessioned2014-10-19T21:22:05Z
dc.date.accessioned2016-09-01T04:06:58Z
dc.date.available2014-10-19T21:22:05Z
dc.date.available2016-09-01T04:06:58Z
dc.date.copyright2014en_NZ
dc.date.issued2014en_NZ
dc.description.abstractUndaria pinnatifida is a species of brown seaweed known to contain rich amounts of fucoidan, a sulfated polysaccharide known to possess various biological activities. We isolated crude fucoidan (F0) from the sporophylls of U. pinnatifida grown in the Marlborough Sounds, New Zealand. Sulfate content, uronic acid content, and molecular weight of F0 were 15.02, 1.24, and >150 kDa, respectively. F0 was fractionated to yield three further fractions: F1, F2, and F3. Cytotoxicity of two major fractions was determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The algal fucoidans specifically suppressed the proliferation of three cancer cell lines with less cytotoxicity against the normal cells. Selective cytotoxicity could relate to the distinctive structures of each fucoidan fraction. Results from this study provide evidence that fucoidan, especially from U. pinnatifida grown in New Zealand, possesses great potential to be used as a functional food to reduce cancer risk or supplement cancer treatment.en_NZ
dc.identifier.citationFrontiers in Nutrition, vol.1(9), doi: 10.3389/fnut.2014.00009en_NZ
dc.identifier.doi10.3389/fnut.2014.00009en_NZ
dc.identifier.urihttps://hdl.handle.net/10292/10014
dc.publisherFrontiers Media S. A.
dc.relation.replaceshttp://hdl.handle.net/10292/7736
dc.relation.replaces10292/7736
dc.relation.urihttp://dx.doi.org/10.3389/fnut.2014.00009
dc.rightsFrontiers is fully compliant with open access mandates, by publishing its articles under the Creative Commons Attribution licence (CC-BY). Funder mandates such as those by the Wellcome Trust (UK), National Institutes of Health (USA) and the Australian Research Council (Australia) are fully compatible with publishing in Frontiers. Authors retain copyright of their work and can deposit their publication in any repository. The work can be freely shared and adapted provided that appropriate credit is given and any changes specified.
dc.rights.accessrightsOpenAccessen_NZ
dc.subjectFucoidan; Cytotoxicity; Fractionation; Undaria pinnatifida; Sporophyll; Extraction
dc.titleAnti-proliferation Potential and Content of Fucoidan Extracted From Sporophyll of New Zealand Undaria Pinnatifidaen_NZ
dc.typeJournal Article
pubs.elements-id169972
pubs.organisational-data/AUT
pubs.organisational-data/AUT/Health & Environmental Science
pubs.organisational-data/AUT/Health & Environmental Science/Health Faculty Office
pubs.organisational-data/AUT/Health & Environmental Science/Interprofessional Health
pubs.organisational-data/AUT/Health & Environmental Science/School of Science
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