Effective disaster response highly depends on disaster types, scale, and attributes of disaster affected regions. Although deeply interconnected, social, cyber and physical aspects are usually not considered together when shaping an appropriate disaster response strategy. We introduce a conceptual framework in which disasters are socio-cyber-physical systems that codify attributes impacting effective responses. The framework enables rigorous analysis and evaluation of response plans by disaster managers. We inform our conceptual model through a range of disaster-response case studies and our personal disaster first-responder experiences.