Investigation of Different Molecular Weight Fucoidan Fractions Derived from New Zealand Undaria pinnatifida in Combination with GroA Therapy in Prostate Cancer Cell Lines

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aut.relation.issue11en_NZ
aut.relation.journalMarine Drugsen_NZ
aut.relation.volume16en_NZ
aut.researcherLu, Jun
dc.contributor.authorYang, Xen_NZ
dc.contributor.authorWang, Sen_NZ
dc.contributor.authorTrangle, SSen_NZ
dc.contributor.authorLi, Yen_NZ
dc.contributor.authorWhite, WLen_NZ
dc.contributor.authorLi, Jen_NZ
dc.contributor.authorYing, Ten_NZ
dc.contributor.authorKong, Qen_NZ
dc.contributor.authorZhao, Yen_NZ
dc.contributor.authorLu, Jen_NZ
dc.date.accessioned2019-04-09T00:00:13Z
dc.date.available2019-04-09T00:00:13Z
dc.date.copyright2018en_NZ
dc.date.issued2018en_NZ
dc.description.abstractFucoidan, a sulfated polysaccharide extracted from brown seaweeds, has been shown to possess various antioxidant, anticoagulant, antiviral, and anticancer functions. In this study, we focused on low molecular weight fucoidan (LMWF) which was extracted from New Zealand Undaria pinnatifida, and investigated its anti-proliferative effects, combined with a quadruplex-forming oligonucleotide aptamer (GroA, AS1411), a powerful cell surface Nucleolin inhibitor, in prostate cancer cells. We examined LMWF (<10 kDa) and compared it with laboratory grade Fucoidan purchased from Sigma (FS), all extracted from the same seaweed species U. pinnatifida. We found that LMWF significantly improved the anti-proliferative effect of GroA, as it decreased cancer cell growth and viability and increased cell death. This research may provide the foundation for LMWF to be used against prostate cancers as a supplement therapy in combination with other therapeutic agents.en_NZ
dc.identifier.citationMarine Drugs, 16(11), 454. doi:10.3390/md16110454
dc.identifier.doi10.3390/md16110454en_NZ
dc.identifier.issn1660-3397en_NZ
dc.identifier.issn1660-3397en_NZ
dc.identifier.urihttps://hdl.handle.net/10292/12428
dc.publisherMDPI AGen_NZ
dc.relation.urihttps://www.mdpi.com/1660-3397/16/11/454
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
dc.rights.accessrightsOpenAccessen_NZ
dc.subjectFucoidan; Low molecular weight fucoidan; Nucleolin; GroA; Prostate cancer; Undaria pinnatifida
dc.titleInvestigation of Different Molecular Weight Fucoidan Fractions Derived from New Zealand Undaria pinnatifida in Combination with GroA Therapy in Prostate Cancer Cell Linesen_NZ
dc.typeJournal Article
pubs.elements-id349937
pubs.organisational-data/AUT
pubs.organisational-data/AUT/Health & Environmental Science
pubs.organisational-data/AUT/Health & Environmental Science/Interprofessional Health
pubs.organisational-data/AUT/PBRF
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences/HA Science 2018 PBRF
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences/HI Interprofessional 2018 PBRF
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