Light-Switchable Membrane Permeability in Giant Unilamellar Vesicles

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aut.relation.issue12
aut.relation.journalPharmaceutics
aut.relation.startpage2777
aut.relation.volume14
dc.contributor.authorAlbanese, P
dc.contributor.authorCataldini, S
dc.contributor.authorRen, CZJ
dc.contributor.authorValletti, N
dc.contributor.authorBrunetti, J
dc.contributor.authorChen, JLY
dc.contributor.authorRossi, F
dc.date.accessioned2023-06-02T04:04:02Z
dc.date.available2023-06-02T04:04:02Z
dc.date.issued2022-12-12
dc.description.abstractIn this work, giant unilamellar vesicles (GUVs) were synthesized by blending the natural phospholipid 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) with a photoswitchable amphiphile (1) that undergoes photoisomerization upon irradiation with UV-A (E to Z) and blue (Z to E) light. The mixed vesicles showed marked changes in behavior in response to UV light, including changes in morphology and the opening of pores. The fine control of membrane permeability with consequent cargo release could be attained by modulating either the UV irradiation intensity or the membrane composition. As a proof of concept, the photocontrolled release of sucrose from mixed GUVs is demonstrated using microscopy (phase contrast) and confocal studies. The permeability of the GUVs to sucrose could be increased to ~4 × 10–2 μm/s when the system was illuminated by UV light. With respect to previously reported systems (entirely composed of synthetic amphiphiles), our findings demonstrate the potential of photosensitive GUVs that are mainly composed of natural lipids to be used in medical and biomedical applications, such as targeted drug delivery and localized topical treatments.
dc.identifier.citationPharmaceutics, ISSN: 1999-4923 (Print); 1999-4923 (Online), MDPI AG, 14(12), 2777-. doi: 10.3390/pharmaceutics14122777
dc.identifier.doi10.3390/pharmaceutics14122777
dc.identifier.issn1999-4923
dc.identifier.issn1999-4923
dc.identifier.urihttps://hdl.handle.net/10292/16212
dc.languageeng
dc.publisherMDPI AG
dc.relation.urihttps://www.mdpi.com/1999-4923/14/12/2777
dc.rights.accessrightsOpenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectazobenzene
dc.subjectgiant vesicles
dc.subjectlight-responsive vesicles
dc.subjectphotoswitchable amphiphiles
dc.subjectsmart materials
dc.subjectstimulus-responsive membranes
dc.subjectsystems chemistry
dc.subjecttargeted drug delivery
dc.subject3214 Pharmacology and Pharmaceutical Sciences
dc.subject32 Biomedical and Clinical Sciences
dc.subject1115 Pharmacology and Pharmaceutical Sciences
dc.subject3214 Pharmacology and pharmaceutical sciences
dc.titleLight-Switchable Membrane Permeability in Giant Unilamellar Vesicles
dc.typeJournal Article
pubs.elements-id489084
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