Roadmap for an Imaging and Modelling Paediatric Study in Rural NZ

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aut.relation.journalFrontiers in Physiology
aut.relation.startpage1104838
aut.relation.volume14
dc.contributor.authorKumar, H
dc.contributor.authorGreen, R
dc.contributor.authorCornfeld, DM
dc.contributor.authorCondron, P
dc.contributor.authorEmsden, T
dc.contributor.authorElsayed, A
dc.contributor.authorZhao, D
dc.contributor.authorGilbert, K
dc.contributor.authorNash, MP
dc.contributor.authorClark, AR
dc.contributor.authorTawhai, MH
dc.contributor.authorBurrowes, K
dc.contributor.authorMurphy, R
dc.contributor.authorTayebi, M
dc.contributor.authorMcGeown, J
dc.contributor.authorKwon, E
dc.contributor.authorShim, V
dc.contributor.authorWang, A
dc.contributor.authorChoisne, J
dc.contributor.authorCarman, L
dc.contributor.authorBesier, T
dc.contributor.authorHandsfield, G
dc.contributor.authorBabarenda Gamage, TP
dc.contributor.authorShen, J
dc.contributor.authorMaso Talou, G
dc.contributor.authorSafaei, S
dc.contributor.authorMaller, JJ
dc.contributor.authorTaylor, D
dc.contributor.authorPotter, L
dc.contributor.authorHoldsworth, SJ
dc.contributor.authorWilson, GA
dc.date.accessioned2023-05-15T22:57:47Z
dc.date.available2023-05-15T22:57:47Z
dc.date.issued2023-03-10
dc.description.abstractOur study methodology is motivated from three disparate needs: one, imaging studies have existed in silo and study organs but not across organ systems; two, there are gaps in our understanding of paediatric structure and function; three, lack of representative data in New Zealand. Our research aims to address these issues in part, through the combination of magnetic resonance imaging, advanced image processing algorithms and computational modelling. Our study demonstrated the need to take an organ-system approach and scan multiple organs on the same child. We have pilot tested an imaging protocol to be minimally disruptive to the children and demonstrated state-of-the-art image processing and personalized computational models using the imaging data. Our imaging protocol spans brain, lungs, heart, muscle, bones, abdominal and vascular systems. Our initial set of results demonstrated child-specific measurements on one dataset. This work is novel and interesting as we have run multiple computational physiology workflows to generate personalized computational models. Our proposed work is the first step towards achieving the integration of imaging and modelling improving our understanding of the human body in paediatric health and disease.
dc.identifier.citationFrontiers in Physiology, ISSN: 1664-042X (Print); 1664-042X (Online), Frontiers Media SA, 14, 1104838-. doi: 10.3389/fphys.2023.1104838
dc.identifier.doi10.3389/fphys.2023.1104838
dc.identifier.issn1664-042X
dc.identifier.issn1664-042X
dc.identifier.urihttps://hdl.handle.net/10292/16134
dc.languageeng
dc.publisherFrontiers Media SA
dc.relation.urihttps://www.frontiersin.org/articles/10.3389/fphys.2023.1104838/full
dc.rights.accessrightsOpenAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectMRI image analysis
dc.subjectchild health and development
dc.subjectcomputational modelling
dc.subjectneuroimage analysis
dc.subjectradiology
dc.subject3101 Biochemistry and Cell Biology
dc.subject3208 Medical Physiology
dc.subject32 Biomedical and Clinical Sciences
dc.subject31 Biological Sciences
dc.subjectBiomedical Imaging
dc.subjectBioengineering
dc.subject1 Underpinning research
dc.subject1.1 Normal biological development and functioning
dc.subjectGeneric health relevance
dc.subjectCardiovascular
dc.subject3 Good Health and Well Being
dc.subject0606 Physiology
dc.subject1116 Medical Physiology
dc.subject1701 Psychology
dc.subject3101 Biochemistry and cell biology
dc.subject3208 Medical physiology
dc.titleRoadmap for an Imaging and Modelling Paediatric Study in Rural NZ
dc.typeJournal Article
pubs.elements-id497347
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