The Effect of an Autoimmune Protocol (AIP) Diet in Adults With Rheumatoid Arthritis: A Single Arm Crossover Pilot Feasibility Study
Date
Authors
McNeill, JJ
Mearns, GJ
Grainger, R
Zinn, C
Supervisor
Item type
Journal Article
Degree name
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley
Abstract
Background: Individuals with rheumatoid arthritis (RA) often ask whether dietary changes or food exclusions can reduce symptoms. The Autoimmune Protocol (AIP) diet, an elimination-based approach, is popular on social media, with anecdotal reports of benefit, but lacks clinical evaluation in RA. Objectives: To assess the feasibility and effectiveness of an AIP diet on patient-reported outcomes (PROs) in adults with RA. Methods: In this single-arm, open-label pilot study, nine adults with RA followed their usual diet for 4 weeks and then an 8-week AIP diet in a free-living context. Weekly PRO measures included the Routine Assessment of Patient Index Data 3 (RAPID3) and RA Impact of Disease (RAID) as primary outcomes. Secondary outcomes included 3-day weighed food records and biometric measurements (weight and waist circumference) collected at baseline and every 4 weeks. Adherence and ease of implementation were recorded weekly. Results: Nine participants (7 females, 2 males, aged 40–63 years) completed the intervention. From baseline to end week 12, mean RAPID3 scores decreased from 2.73/10 (range 0.2–5.37) to 0.99 (0–2.5). Four participants demonstrated a clinically meaningful reduction and three others reached remission from low disease activity. Mean RAID scores decreased from 3.13/10 (0.1–6.35) to 1.02 (0–2.96). Fatigue, sleep and pain improved. Mean body mass index reduced from 26.3 kg/m2 to 24.5 kg/m2. The diet was feasible with high adherence. Conclusions: An 8-week AIP diet was associated with improvements in PROs in seven of nine participants. These pilot findings support further controlled trials to confirm efficacy and explore mechanisms as a potential adjunct therapy for RA. Trial Registration: Number ACTRN12624001391561. https://www.anzctr.org.au/ACTRN12624001391561.aspx.Description
Keywords
AIP diet, RAID, RAPID3, autoimmune protocol diet, nutrition, patient‐reported outcomes, rheumatoid arthritis, 4205 Nursing, 42 Health Sciences, Clinical Research, Pain Research, Autoimmune Disease, Clinical Trials and Supportive Activities, Nutrition, Arthritis, Women's Health, Behavioral and Social Science, Rheumatoid Arthritis, Inflammatory and immune system, 1110 Nursing, Arthritis & Rheumatology
Source
Musculoskeletal Care, ISSN: 1478-2189 (Print); 1557-0681 (Online), Wiley, 24(2), e70214-. doi: 10.1002/msc.70214
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Rights statement
© 2026 The Author(s). Musculoskeletal Care published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.