Sedentary Time is Independently Related to Adipose Tissue Insulin Resistance in Adults With or at Risk of Type 2 Diabetes
Date
Authors
Engin, Buket
Willis, Scott A
Malaikah, Sundus
Sargeant, Jack A
Biddle, Gregory JH
Razieh, Cameron
Argyridou, Stavroula
Edwardson, Charlotte L
Jelleyman, Charlotte
Stensel, David J
Supervisor
Item type
Journal Article
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Journal Title
Journal ISSN
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Publisher
Lippincott, Williams & Wilkins
Abstract
INTRODUCTION: This cross-sectional study examined associations of device-measured sedentary time and moderate-to-vigorous physical activity (MVPA) with adipose tissue insulin resistance in people with or at high-risk of type 2 diabetes (T2DM). METHODS: Data were combined from six previous experimental studies (within our group) involving patients with T2DM or primary risk factors (median (IQR) age 66.2 (66.0 - 70.8) years, body mass index (BMI) 31.1 (28.0 - 34.4) kg.m-2, 62% male, n = 179). Adipose tissue insulin resistance was calculated as the product of fasted circulating insulin and non-esterified fatty acids (ADIPO-IR), while sedentary time and MVPA were determined from wrist-worn accelerometery. Generalised linear models examined associations of sedentary time and MVPA with ADIPO-IR with interaction terms added to explore the moderating influence of ethnicity (white European vs. south Asian), BMI, age, and sex. RESULTS: In finally-adjusted models, sedentary time was positively associated with ADIPO-IR, with every 30-min of sedentary time associated with a 1.80 (95% CI: 0.51 to 3.06; P = 0.006) unit higher ADIPO-IR. This relationship strengthened as BMI increased (β = 3.48 [95%CI = 1.50 to 5.46], P = 0.005 in the upper BMI tertile [≥ 33.2 kg.m-2]). MVPA was unrelated to ADIPO-IR. These results were consistent in sensitivity analyses that excluded participants taking statins and/or metformin (n = 126) and when separated into the participants with T2DM (n = 32) and those at-high-risk (n = 147). CONCLUSIONS: Sedentary time is positively related to adipose tissue insulin sensitivity in people with or at high-risk of T2DM. This relationship strengthens as BMI increases and may help explain established relationships between greater sedentary time, ectopic lipid, and hyperglycaemia.Description
Keywords
32 Biomedical and Clinical Sciences, 4206 Public Health, 42 Health Sciences, 3202 Clinical Sciences, Clinical Research, Obesity, Nutrition, Diabetes, Prevention, Metabolic and endocrine, 1106 Human Movement and Sports Sciences, 1116 Medical Physiology, 1117 Public Health and Health Services, Sport Sciences, 3202 Clinical sciences, 3208 Medical physiology, 4207 Sports science and exercise
Source
Medicine and Science in Sports and Exercise, ISSN: 0195-9131 (Print); 1530-0315 (Online), Lippincott, Williams & Wilkins, 55(9), 1548-1554. doi: 10.1249/MSS.0000000000003193
Rights statement
This is the Author's Accepted Manuscript of an article published in Medicine and Science in Sports and Exercise © 2023 by the American College of Sports Medicine. The Version of Record is available, free access, at DOI: 10.1249/MSS.0000000000003193