Light-Activated Communication Between Synthetic and Living Cells via Photoresponsive Membranes
Loading...
Files
Size: 1.24 MB, File format: Adobe PDF
Date
Authors
Barbaro, Roberto
Albanese, Paola
Colella, Matilde
Lattarulo, Davide
Saha, Samrat
Chen, Jack L-Y
Mavelli, Fabio
Rossi, Federico
Altamura, Emiliano
Supervisor
Item type
Degree name
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley
Abstract
Synthetic cells (SCs) are programmable biomimetic systems that reproduce selected cellular functions while offering high structural and functional controllability. A particularly attractive feature of SCs is their ability to respond to external stimuli, enabling regulated cargo release and communication with living cells. Here, we report a light-responsive SC platform capable of establishing chemically mediated communication with human cancer cells. Upon light stimulation, the SCs release signaling molecules, such as adenosine triphosphate (ATP) and histamine, that activate intracellular calcium signaling pathways in target cells. These results demonstrate the feasibility of remotely controlled communication between synthetic and living cells and highlight the potential of SCs as bio-hybrid interfaces for precise cellular modulation, therapeutic delivery, artificial organelles, and other biomedical applications.
Description
Keywords
biomimetic membranes, cell signaling, cell to cell communication, controlled delivery, photoswitch, rupture of membranes, signal transduction, synthetic cells, 3101 Biochemistry and Cell Biology, 31 Biological Sciences, Cancer, Biotechnology, Bioengineering, Generic health relevance, 0304 Medicinal and Biomolecular Chemistry, 0601 Biochemistry and Cell Biology, Organic Chemistry, 3101 Biochemistry and cell biology, 3404 Medicinal and biomolecular chemistry
Source
Chembiochem, ISSN: 1439-4227 (Print); 1439-7633 (Online), Wiley, 27(14), e70469-. doi: 10.1002/cbic.70469
Publisher's version
Rights statement
Creative Commons Attribution
Permanent link
Collections
Endorsement
Review
Supplemented By
Referenced By
Creative Commons license
Except where otherwise noted, this item's license is described as Creative Commons Attribution