Resting-State Amygdala Subregion and Precuneus Connectivity Provide Evidence for a Dimensional Approach to Studying Social Anxiety Disorder

Simple item page
aut.relation.articlenumber147
aut.relation.issue1
aut.relation.journalTransl Psychiatry
aut.relation.startpage147
aut.relation.volume14
dc.contributor.authorMizzi, Simone
dc.contributor.authorPedersen, Mangor
dc.contributor.authorRossell, Susan L
dc.contributor.authorRendell, Peter
dc.contributor.authorTerrett, Gill
dc.contributor.authorHeinrichs, Markus
dc.contributor.authorLabuschagne, Izelle
dc.date.accessioned2024-03-22T03:44:41Z
dc.date.available2024-03-22T03:44:41Z
dc.date.issued2024-03-14
dc.description.abstractSocial anxiety disorder (SAD) is a prevalent and disabling mental health condition, characterized by excessive fear and anxiety in social situations. Resting-state functional magnetic resonance imaging (fMRI) paradigms have been increasingly used to understand the neurobiological underpinnings of SAD in the absence of threat-related stimuli. Previous studies have primarily focused on the role of the amygdala in SAD. However, the amygdala consists of functionally and structurally distinct subregions, and recent studies have highlighted the importance of investigating the role of these subregions independently. Using multiband fMRI, we analyzed resting-state data from 135 participants (42 SAD, 93 healthy controls). By employing voxel-wise permutation testing, we examined group differences of fMRI connectivity and associations between fMRI connectivity and social anxiety symptoms to further investigate the classification of SAD as a categorical or dimensional construct. Seed-to-whole brain functional connectivity analysis using multiple 'seeds' including the amygdala and its subregions and the precuneus, revealed no statistically significant group differences. However, social anxiety severity was significantly negatively correlated with functional connectivity of the precuneus - perigenual anterior cingulate cortex and positively correlated with functional connectivity of the amygdala (specifically the superficial subregion) - parietal/cerebellar areas. Our findings demonstrate clear links between symptomatology and brain connectivity in the absence of diagnostic differences, with evidence of amygdala subregion-specific alterations. The observed brain-symptom associations did not include disturbances in the brain's fear circuitry (i.e., disturbances in connectivity between amygdala - prefrontal regions) likely due to the absence of threat-related stimuli.
dc.identifier.citationTransl Psychiatry, ISSN: 2158-3188 (Print); 2158-3188 (Online), Springer Science and Business Media LLC, 14(1), 147-. doi: 10.1038/s41398-024-02844-9
dc.identifier.doi10.1038/s41398-024-02844-9
dc.identifier.issn2158-3188
dc.identifier.issn2158-3188
dc.identifier.urihttp://hdl.handle.net/10292/17366
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.relation.urihttps://www.nature.com/articles/s41398-024-02844-9
dc.rightsOpen Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
dc.rights.accessrightsOpenAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject5202 Biological Psychology
dc.subject52 Psychology
dc.subjectBehavioral and Social Science
dc.subjectMental Health
dc.subjectBrain Disorders
dc.subjectBasic Behavioral and Social Science
dc.subjectAnxiety Disorders
dc.subjectNeurosciences
dc.subjectClinical Research
dc.subjectNeurological
dc.subjectMental health
dc.subject3 Good Health and Well Being
dc.subject1103 Clinical Sciences
dc.subject1117 Public Health and Health Services
dc.subject1701 Psychology
dc.subject3202 Clinical sciences
dc.subject3209 Neurosciences
dc.subject5202 Biological psychology
dc.subject.meshHumans
dc.subject.meshPhobia, Social
dc.subject.meshAmygdala
dc.subject.meshAnxiety Disorders
dc.subject.meshBrain
dc.subject.meshParietal Lobe
dc.subject.meshBrain Mapping
dc.subject.meshMagnetic Resonance Imaging
dc.titleResting-State Amygdala Subregion and Precuneus Connectivity Provide Evidence for a Dimensional Approach to Studying Social Anxiety Disorder
dc.typeJournal Article
pubs.elements-id542167
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
s41398-024-02844-9.pdf
Size:
2.22 MB
Format:
Adobe Portable Document Format
Description:
Journal article
Download
Collections
School of Clinical Sciences