Metabolic Biomarkers of Monochorionic Twins Complicated With Selective Intrauterine Growth Restriction in Cord Plasma and Placental Tissue
aut.relation.issue | 1 | en_NZ |
aut.relation.journal | Scientific Reports | en_NZ |
aut.relation.volume | 8 | en_NZ |
aut.researcher | Young, Timothy | |
dc.contributor.author | Wang, L | en_NZ |
dc.contributor.author | Han, TL | en_NZ |
dc.contributor.author | Luo, X | en_NZ |
dc.contributor.author | Li, S | en_NZ |
dc.contributor.author | Young, T | en_NZ |
dc.contributor.author | Chen, C | en_NZ |
dc.contributor.author | Wen, L | en_NZ |
dc.contributor.author | Xu, P | en_NZ |
dc.contributor.author | Zheng, Y | en_NZ |
dc.contributor.author | Saffery, R | en_NZ |
dc.contributor.author | Baker, PN | en_NZ |
dc.contributor.author | Tong, C | en_NZ |
dc.contributor.author | Qi, H | en_NZ |
dc.date.accessioned | 2019-04-30T02:36:12Z | |
dc.date.available | 2019-04-30T02:36:12Z | |
dc.date.copyright | 2018-12-01 | en_NZ |
dc.date.issued | 2018-12-01 | en_NZ |
dc.description.abstract | The selective intrauterine growth restriction (sIUGR) of monochorionic diamniotic (MCDC) twins causes phenotypic growth discordance, which is correlated with metabolomic pertubations. A global, untargeted identification of the metabolic fingerprint may help elucidate the etiology of sIUGR. Umbilical cord blood and placentas collected from 15 pairs of sIUGR monochorionic twins, 24 pairs of uncomplicated twins, and 14 singletons diagnosed with intrauterine growth restriction (IUGR) were subjected to gas chromatography-mass spectrometry based metabolomic analyses. Supervised multivariate regression analysis and pathway analysis were performed to compare control twins with sIUGR twins. A generalized estimating equation (GEE) model was utilized to explore metabolic differences within sIUGR co-twins. Linear logistic regression was applied to screen metabolites that significantly differed in concentration between control twins and sIUGR twins or IUGR singletons. Umbilical cord blood demonstrated better global metabolomic separation of sIUGR and control twins compared to the placenta. Disrupted amino acid and fatty acid metabolism as well as high levels of exposure to environmental xenobiotics were associated with sIUGR. The metabolic abnormalities in MCDA twins suggested that in utero growth discordance is caused by intrauterine and extrauterine environmental factors, rather than genetics. Thus, this study provides new therapeutic targets and strategies for sIUGR management and prevention. | en_NZ |
dc.identifier.citation | Scientific Reports, Volume 8, Article number: 15914 (2018) | |
dc.identifier.doi | 10.1038/s41598-018-33788-y | en_NZ |
dc.identifier.issn | 2045-2322 | en_NZ |
dc.identifier.uri | https://hdl.handle.net/10292/12475 | |
dc.publisher | Springer Nature | |
dc.relation.uri | https://www.nature.com/articles/s41598-018-33788-y | |
dc.rights | © The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Cre-ative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not per-mitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | |
dc.rights.accessrights | OpenAccess | en_NZ |
dc.title | Metabolic Biomarkers of Monochorionic Twins Complicated With Selective Intrauterine Growth Restriction in Cord Plasma and Placental Tissue | en_NZ |
dc.type | Journal Article | |
pubs.elements-id | 348609 | |
pubs.organisational-data | /AUT | |
pubs.organisational-data | /AUT/Health & Environmental Science | |
pubs.organisational-data | /AUT/Health & Environmental Science/Applied Science | |
pubs.organisational-data | /AUT/Health & Environmental Science/School of Science | |
pubs.organisational-data | /AUT/PBRF | |
pubs.organisational-data | /AUT/PBRF/PBRF Health and Environmental Sciences | |
pubs.organisational-data | /AUT/PBRF/PBRF Health and Environmental Sciences/HA Science 2018 PBRF |
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