As the world digitises, children and adolescents are increasingly using digital technologies. These devices offer benefits such as exposure to social contacts and support, potential learning opportunities, and access to health promotion material. However, along with these benefits, emerging evidence is indicating that frequent, extended use of digital technologies is associated with negative impacts on the health and wellbeing of children and adolescents. There are many ways to use digital technologies both for learning and recreation, so understanding the context of use is important when considering these impacts. As the pace of change unfolds, this narrative review provides an overview of the impacts of using digital technologies on the health and wellbeing of children and adolescents across eight areas: vision, hearing, obesity, pain, sleep, cognition, mental health, and social impacts. Key points summarise the current state of evidence with relating expert opinion on reducing the risk of harm (where indicated), with the aim to aid decision-making and risk intervention. Sources include global large-scale studies, systematic reviews, and meta-analyses. Physiotherapists, with a professional scope focusing on physical health, quality of life, health promotion, and advocacy, are well positioned to support children and families, and to contribute to interventions aimed at reducing risk.