Double Sigmoid Model for Fitting Fatigue Profiles in Mouse Fast- and Slow-Twitch Muscle

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aut.relation.endpage862
aut.relation.issue7
aut.relation.journalExperimental Physiology
aut.relation.startpage851
aut.relation.volume93
dc.contributor.authorCairns, SP
dc.contributor.authorRobinson, D
dc.contributor.authorLoiselle, DS
dc.date.accessioned2024-02-07T02:36:46Z
dc.date.available2024-02-07T02:36:46Z
dc.date.issued2008
dc.description.abstractWe present a curve-fitting approach that permits quantitative comparisons of fatigue profiles obtained with different stimulation protocols in isolated slow-twitch soleus and fast-twitch extensor digitorum longus (EDL) muscles of mice. Profiles from our usual stimulation protocol (125 Hz for 500 ms, evoked once every second for 100-300 s) could be fitted by single-term functions (sigmoids or exponentials) but not by a double exponential. A clearly superior fit, as confirmed by the Akaiki Information Criterion, was achieved using a double-sigmoid function. Fitting accuracy was exceptional; mean square errors were typically <1% and r2 > 0.9995. The first sigmoid (early fatigue) involved ∼10% decline of isometric force to an intermediate plateau in both muscle types; the second sigmoid (late fatigue) involved a reduction of force to a final plateau, the decline being 83% of initial force in EDL and 63% of initial force in soleus. The maximal slope of each sigmoid was seven- to eightfold greater in EDL than in soleus. The general applicability of the model was tested by fitting profiles with a severe force loss arising from repeated tetanic stimulation evoked at different frequencies or rest periods, or with excitation via nerve terminals in soleus. Late fatigue, which was absent at 30 Hz, occurred earlier and to a greater extent at 125 than 50 Hz. The model captured small changes in rate of late fatigue for nerve terminal versus sarcolemmal stimulation. We conclude that a double-sigmoid expression is a useful and accurate model to characterize fatigue in isolated muscle preparations. © 2008 The Authors.
dc.identifier.citationExperimental Physiology, ISSN: 0958-0670 (Print); 1469-445X (Online), WILEY-BLACKWELL, 93(7), 851-862. doi: 10.1113/expphysiol.2007.041285
dc.identifier.doi10.1113/expphysiol.2007.041285
dc.identifier.issn0958-0670
dc.identifier.issn1469-445X
dc.identifier.urihttp://hdl.handle.net/10292/17189
dc.languageeng
dc.publisherWILEY-BLACKWELL
dc.relation.urihttps://physoc.onlinelibrary.wiley.com/doi/10.1113/expphysiol.2007.041285
dc.rights© 2008 The Authors. Free access.
dc.rights.accessrightsOpenAccess
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectPhysiology
dc.subjectMAMMALIAN SKELETAL-MUSCLE
dc.subjectINORGANIC-PHOSPHATE
dc.subjectFORCE DECLINE
dc.subjectTETANIC FORCE
dc.subjectSOLEUS MUSCLE
dc.subjectRAT HINDLIMB
dc.subjectMOTOR UNITS
dc.subjectP-I
dc.subjectSTIMULATION
dc.subjectFIBERS
dc.subject3208 Medical Physiology
dc.subject32 Biomedical and Clinical Sciences
dc.subjectNeurosciences
dc.subject1 Underpinning research
dc.subject1.1 Normal biological development and functioning
dc.subject0606 Physiology
dc.subject1106 Human Movement and Sports Sciences
dc.subject1116 Medical Physiology
dc.subjectPhysiology
dc.subject3109 Zoology
dc.subject3208 Medical physiology
dc.subject4207 Sports science and exercise
dc.subject.meshAnimals
dc.subject.meshElectric Stimulation
dc.subject.meshFemale
dc.subject.meshMice
dc.subject.meshModels, Animal
dc.subject.meshModels, Biological
dc.subject.meshMuscle Fatigue
dc.subject.meshMuscle Fibers, Fast-Twitch
dc.subject.meshMuscle Fibers, Slow-Twitch
dc.subject.meshMuscle, Skeletal
dc.subject.meshMuscle Fibers, Fast-Twitch
dc.subject.meshMuscle Fibers, Slow-Twitch
dc.subject.meshMuscle, Skeletal
dc.subject.meshAnimals
dc.subject.meshMice
dc.subject.meshModels, Animal
dc.subject.meshElectric Stimulation
dc.subject.meshMuscle Fatigue
dc.subject.meshModels, Biological
dc.subject.meshFemale
dc.subject.meshAnimals
dc.subject.meshElectric Stimulation
dc.subject.meshFemale
dc.subject.meshMice
dc.subject.meshModels, Animal
dc.subject.meshModels, Biological
dc.subject.meshMuscle Fatigue
dc.subject.meshMuscle Fibers, Fast-Twitch
dc.subject.meshMuscle Fibers, Slow-Twitch
dc.subject.meshMuscle, Skeletal
dc.titleDouble Sigmoid Model for Fitting Fatigue Profiles in Mouse Fast- and Slow-Twitch Muscle
dc.typeJournal Article
pubs.elements-id12281
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