Locally Applied Heat Stress During Exercise Training May Promote Adaptations to Mitochondrial Enzyme Activities in Skeletal Muscle

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aut.relation.endpage948
aut.relation.issue6
aut.relation.journalPfluegers Archiv: European journal of physiology
aut.relation.startpage939
aut.relation.volume476
dc.contributor.authorMaunder, Ed
dc.contributor.authorKing, Andrew
dc.contributor.authorRothschild, Jeffrey A
dc.contributor.authorBrick, Matthew J
dc.contributor.authorLeigh, Warren B
dc.contributor.authorHedges, Christopher P
dc.contributor.authorMerry, Troy L
dc.contributor.authorKilding, Andrew E
dc.date.accessioned2024-11-12T01:47:51Z
dc.date.available2024-11-12T01:47:51Z
dc.date.issued2024-03-06
dc.description.abstractThere is some evidence for temperature-dependent stimulation of mitochondrial biogenesis; however, the role of elevated muscle temperature during exercise in mitochondrial adaptation to training has not been studied in humans in vivo. The purpose of this study was to determine the role of elevating muscle temperature during exercise in temperate conditions through the application of mild, local heat stress on mitochondrial adaptations to endurance training. Eight endurance-trained males undertook 3 weeks of supervised cycling training, during which mild (~ 40 °C) heat stress was applied locally to the upper-leg musculature of one leg during all training sessions (HEAT), with the contralateral leg serving as the non-heated, exercising control (CON). Vastus lateralis microbiopsies were obtained from both legs before and after the training period. Training-induced increases in complex I (fold-change, 1.24 ± 0.33 vs. 1.01 ± 0.49, P = 0.029) and II (fold-change, 1.24 ± 0.33 vs. 1.01 ± 0.49, P = 0.029) activities were significantly larger in HEAT than CON. No significant effects of training, or interactions between local heat stress application and training, were observed for complex I-V or HSP70 protein expressions. Our data provides partial evidence to support the hypothesis that elevating local muscle temperature during exercise augments training-induced adaptations to mitochondrial enzyme activity.
dc.identifier.citationPfluegers Archiv: European journal of physiology, ISSN: 0031-6768 (Print); 0031-6768 (Online), Springer, 476(6), 939-948. doi: 10.1007/s00424-024-02939-8
dc.identifier.doi10.1007/s00424-024-02939-8
dc.identifier.issn0031-6768
dc.identifier.issn0031-6768
dc.identifier.urihttp://hdl.handle.net/10292/18292
dc.languageeng
dc.publisherSpringer
dc.relation.urihttps://link.springer.com/article/10.1007/s00424-024-02939-8
dc.rightsOpen Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
dc.rights.accessrightsOpenAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectExercise
dc.subjectHeat
dc.subjectMitochondria
dc.subjectMuscle
dc.subjectExercise
dc.subjectHeat
dc.subjectMitochondria
dc.subjectMuscle
dc.subject3109 Zoology
dc.subject3101 Biochemistry and Cell Biology
dc.subject31 Biological Sciences
dc.subjectPhysical Activity
dc.subject6.7 Physical
dc.subject0606 Physiology
dc.subject1106 Human Movement and Sports Sciences
dc.subject1116 Medical Physiology
dc.subjectPhysiology
dc.subject3101 Biochemistry and cell biology
dc.subject3109 Zoology
dc.subject3208 Medical physiology
dc.subject.meshMale
dc.subject.meshHumans
dc.subject.meshAdaptation, Physiological
dc.subject.meshMuscle, Skeletal
dc.subject.meshExercise
dc.subject.meshAdult
dc.subject.meshHeat-Shock Response
dc.subject.meshMitochondria, Muscle
dc.subject.meshHot Temperature
dc.subject.meshElectron Transport Complex I
dc.subject.meshYoung Adult
dc.subject.meshElectron Transport Complex II
dc.subject.meshMuscle, Skeletal
dc.subject.meshMitochondria, Muscle
dc.subject.meshHumans
dc.subject.meshElectron Transport Complex I
dc.subject.meshElectron Transport Complex II
dc.subject.meshExercise
dc.subject.meshAdaptation, Physiological
dc.subject.meshHeat-Shock Response
dc.subject.meshAdult
dc.subject.meshMale
dc.subject.meshHot Temperature
dc.subject.meshYoung Adult
dc.subject.meshMale
dc.subject.meshHumans
dc.subject.meshAdaptation, Physiological
dc.subject.meshMuscle, Skeletal
dc.subject.meshExercise
dc.subject.meshAdult
dc.subject.meshHeat-Shock Response
dc.subject.meshMitochondria, Muscle
dc.subject.meshHot Temperature
dc.subject.meshElectron Transport Complex I
dc.subject.meshYoung Adult
dc.subject.meshElectron Transport Complex II
dc.titleLocally Applied Heat Stress During Exercise Training May Promote Adaptations to Mitochondrial Enzyme Activities in Skeletal Muscle
dc.typeJournal Article
pubs.elements-id540673
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