The Hepatokine Leukocyte Cell-Derived Chemotaxin-2 Is Elevated in People with Impaired Glycaemic Regulation and Augmented by Acute Exercise

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aut.relation.endpage62
aut.relation.issue1
aut.relation.journalLivers
aut.relation.startpage51
aut.relation.volume4
dc.contributor.authorEngin, Buket
dc.contributor.authorWillis, Scott A
dc.contributor.authorMalaikah, Sundus
dc.contributor.authorSargeant, Jack A
dc.contributor.authorStensel, David J
dc.contributor.authorJelleyman, Charlotte
dc.contributor.authorEnnequin, Gaël
dc.contributor.authorAithal, Guruprasad P
dc.contributor.authorYates, Thomas
dc.contributor.authorKing, James A
dc.date.accessioned2024-01-31T01:09:33Z
dc.date.available2024-01-31T01:09:33Z
dc.date.issued2024-01-17
dc.description.abstractThe hepatokine leukocyte cell-derived chemotaxin-2 (LECT2) promotes insulin resistance and hepatic fibrogenesis. In rodents, acute exercise suppresses circulating LECT2; however, human data are lacking. This study compared circulating LECT2 across populations and explored whether acute exercise impacts circulating LECT2. In Part A (n = 43), data were pooled from three experimental studies, regarding the following groups: healthy individuals, individuals with impaired glycaemic regulation (IGR), and individuals with type 2 diabetes and metabolic dysfunction-associated steatotic liver disease (T2DM-MASLD). Generalised linear models assessed differences in circulating LECT2 among groups. Part B (n = 20) involved exercise (30 min, 65% peak oxygen uptake) and control (resting) trials in the healthy and IGR groups. Circulating LECT2 was measured before and at 0, 1, 2 and 3 h post-exercise. Generalised estimating equations assessed differences in LECT2 responses to the trials among groups. In Part A, circulating LECT2 levels were 28.7% and 37.3% higher in the IGR and T2DM-MASLD groups, vs. healthy individuals (p ≤ 0.038), with BMI identified as the main predictor (p = 0.008). In Part B, average circulating LECT2 levels were 6.3% higher after exercise vs. in the control (p < 0.001), with similar responses between groups (p = 0.829). In the combined cohort, circulating LECT2 levels were elevated 1–3 h after exercise vs. control (p ≤ 0.009). LECT2 is elevated in people with dysglycaemia, with BMI as a leading predictor. Contrary to previous rodent work, acute exercise augments, rather than suppresses, circulating LECT2 in humans.
dc.identifier.citationLivers, ISSN: 2673-4389 (Print); 2673-4389 (Online), MDPI AG, 4(1), 51-62. doi: 10.3390/livers4010005
dc.identifier.doi10.3390/livers4010005
dc.identifier.issn2673-4389
dc.identifier.issn2673-4389
dc.identifier.urihttp://hdl.handle.net/10292/17166
dc.languageen
dc.publisherMDPI AG
dc.relation.urihttps://www.mdpi.com/2673-4389/4/1/5
dc.rights© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
dc.rights.accessrightsOpenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject42 Health Sciences
dc.subject4207 Sports Science and Exercise
dc.subjectClinical Trials and Supportive Activities
dc.subjectClinical Research
dc.subjectDiabetes
dc.subjectMetabolic and endocrine
dc.titleThe Hepatokine Leukocyte Cell-Derived Chemotaxin-2 Is Elevated in People with Impaired Glycaemic Regulation and Augmented by Acute Exercise
dc.typeJournal Article
pubs.elements-id536517
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