The Impact of CREBRF rs373863828 Pacific-Variant on Infant Body Composition

Amitrano, F
Krishnan, M
Murphy, R
Okesene-Gafa, KAM
Ji, M
Thompson, JMD
Taylor, RS
Merriman, TR
Rush, E
McCowan, M
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Springer Science and Business Media LLC

In Māori and Pacific adults, the CREBRF rs373863828 minor (A) allele is associated with increased body mass index (BMI) but reduced incidence of type-2 and gestational diabetes mellitus. In this prospective cohort study of Māori and Pacific infants, nested within a nutritional intervention trial for pregnant women with obesity and without pregestational diabetes, we investigated whether the rs373863828 A allele is associated with differences in growth and body composition from birth to 12–18 months’ corrected age. Infants with and without the variant allele were compared using generalised linear models adjusted for potential confounding by gestation length, sex, ethnicity and parity, and in a secondary analysis, additionally adjusted for gestational diabetes. Carriage of the rs373863828 A allele was not associated with altered growth and body composition from birth to 6 months. At 12–18 months, infants with the rs373863828 A allele had lower whole-body fat mass [FM 1.4 (0.7) vs. 1.7 (0.7) kg, aMD −0.4, 95% CI −0.7, 0.0, P = 0.05; FM index 2.2 (1.1) vs. 2.6 (1.0) kg/m2 aMD −0.6, 95% CI −1.2,0.0, P = 0.04]. However, this association was not significant after adjustment for gestational diabetes, suggesting that it may be mediated, at least in part, by the beneficial effect of CREBRF rs373863828 A allele on maternal glycemic status.

3215 Reproductive Medicine , 32 Biomedical and Clinical Sciences , Clinical Trials and Supportive Activities , Preterm, Low Birth Weight and Health of the Newborn , Pediatric , Clinical Research , Nutrition , Prevention , Infant Mortality , Perinatal Period - Conditions Originating in Perinatal Period , Obesity , Diabetes , 2 Aetiology , 2.1 Biological and endogenous factors , Metabolic and endocrine , Reproductive health and childbirth
Scientific Reports, ISSN: 2045-2322 (Print); 2045-2322 (Online), Springer Science and Business Media LLC, 14(1), 8825-. doi: 10.1038/s41598-024-59417-5
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