Identification of Candidate Biomarkers for Quality Assessment of Hatchery-reared Mussel Larvae Via GC/MS-based Metabolomics

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aut.relation.endpage95
aut.relation.issue1en_NZ
aut.relation.journalNew Zealand Journal of Marine and Freshwater Researchen_NZ
aut.relation.startpage87
aut.relation.volume49en_NZ
aut.researcherAlfaro, Andrea
dc.contributor.authorYoung, Ten_NZ
dc.contributor.authorAlfaro, ACen_NZ
dc.contributor.authorVillas-Bôas, Sen_NZ
dc.date.accessioned2017-06-06T23:08:57Z
dc.date.available2017-06-06T23:08:57Z
dc.date.copyright2015en_NZ
dc.date.issued2015en_NZ
dc.description.abstractTo ensure environmental and economic sustainability of future aquaculture growth, large-scale hatchery production of mollusc larvae is required. However, variation in larval quality currently limits potential maximum yields. Identification of biomarkers which reflect the immediate physiological condition of larvae during hatchery production could help monitor and determine causes of variation. Metabolomics is well-suited to this task due to its capacity for providing an instantaneous snapshot of the physiology of an organism through analysis of its metabolite profile. As a test, we applied GC/MS-based metabolomics for this purpose. Using a variety of univariate and multivariate feature selection methods, we identified four metabolite–metabolite ratios involving levels of succinate, glycine, alanine, pyroglutamate and myristic acid as candidate biomarkers for assessing mussel larval quality. These metabolites are known to have roles in energy metabolism, osmotic regulation, immune function and cell–cell communication. We anticipate that further investigation of these metabolites and their associated biochemical pathways will yield a more complete understanding of the factors responsible for larval production variability.en_NZ
dc.identifier.citationNew Zealand Journal of Marine and Freshwater Research, 49(1), 87-95.
dc.identifier.doi10.1080/00288330.2014.958504en_NZ
dc.identifier.issn0028-8330en_NZ
dc.identifier.issn1175-8805en_NZ
dc.identifier.urihttps://hdl.handle.net/10292/10528
dc.languageengen_NZ
dc.publisherTaylor and Francis Ltden_NZ
dc.relation.urihttp://www.tandfonline.com/doi/abs/10.1080/00288330.2014.958504
dc.rightsCopyright © 2014 Taylor & Francis. This is a preprint of an article whose final and definitive form has been published in the New Zealand Journal of Marine and Freshwater Research and is available online at: www.tandfonline.com with the open URL of your article (see Publisher’s Version).
dc.rights.accessrightsOpenAccessen_NZ
dc.subjectAquacultureen_NZ
dc.subjectBivalvesen_NZ
dc.subjectLarval physiologyen_NZ
dc.subjectLarval qualityen_NZ
dc.subjectMetabolite profilesen_NZ
dc.subjectMetabolomicsen_NZ
dc.subjectMussel larvaeen_NZ
dc.subjectPerna canaliculusen_NZ
dc.titleIdentification of Candidate Biomarkers for Quality Assessment of Hatchery-reared Mussel Larvae Via GC/MS-based Metabolomicsen_NZ
dc.typeJournal Article
pubs.elements-id179735
pubs.organisational-data/AUT
pubs.organisational-data/AUT/Health & Environmental Science
pubs.organisational-data/AUT/Health & Environmental Science/Applied Science
pubs.organisational-data/AUT/Health & Environmental Science/School of Science
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