Influence of Resistance Training Proximity-to-Failure on Skeletal Muscle Hypertrophy: A Systematic Review With Meta-Analysis

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aut.relation.endpage665
aut.relation.issue3
aut.relation.journalSports Medicine
aut.relation.startpage649
aut.relation.volume53
dc.contributor.authorRefalo, MC
dc.contributor.authorHelms, ER
dc.contributor.authorTrexler, ET
dc.contributor.authorHamilton, DL
dc.contributor.authorFyfe, JJ
dc.date.accessioned2023-07-05T23:54:34Z
dc.date.available2023-07-05T23:54:34Z
dc.date.issued2022-11-05
dc.description.abstractBackground and Objective: This systematic review with meta-analysis investigated the influence of resistance training proximity-to-failure on muscle hypertrophy. Methods: Literature searches in the PubMed, SCOPUS and SPORTDiscus databases identified a total of 15 studies that measured muscle hypertrophy (in healthy adults of any age and resistance training experience) and compared resistance training performed to: (A) momentary muscular failure versus non-failure; (B) set failure (defined as anything other than momentary muscular failure) versus non-failure; or (C) different velocity loss thresholds. Results: There was a trivial advantage for resistance training performed to set failure versus non-failure for muscle hypertrophy in studies applying any definition of set failure [effect size=0.19 (95% confidence interval 0.00, 0.37), p=0.045], with no moderating effect of volume load (p=0.884) or relative load (p=0.525). Given the variability in set failure definitions applied across studies, sub-group analyses were conducted and found no advantage for either resistance training performed to momentary muscular failure versus non-failure for muscle hypertrophy [effect size=0.12 (95% confidence interval −0.13, 0.37), p=0.343], or for resistance training performed to high (>25%) versus moderate (20–25%) velocity loss thresholds [effect size=0.08 (95% confidence interval −0.16, 0.32), p=0.529]. Conclusion: Overall, our main findings suggest that (i) there is no evidence to support that resistance training performed to momentary muscular failure is superior to non-failure resistance training for muscle hypertrophy and (ii) higher velocity loss thresholds, and theoretically closer proximities-to-failure do not always elicit greater muscle hypertrophy. As such, these results provide evidence for a potential non-linear relationship between proximity-to-failure and muscle hypertrophy.
dc.identifier.citationSports Medicine, ISSN: 0112-1642 (Print); 1179-2035 (Online), Springer Science and Business Media LLC, 53(3), 649-665. doi: 10.1007/s40279-022-01784-y
dc.identifier.doi10.1007/s40279-022-01784-y
dc.identifier.issn0112-1642
dc.identifier.issn1179-2035
dc.identifier.urihttp://hdl.handle.net/10292/16373
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.relation.urihttps://link.springer.com/article/10.1007/s40279-022-01784-y
dc.rights.accessrightsOpenAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject4201 Allied Health and Rehabilitation Science
dc.subject42 Health Sciences
dc.subject4207 Sports Science and Exercise
dc.subjectMusculoskeletal
dc.subject0913 Mechanical Engineering
dc.subject1106 Human Movement and Sports Sciences
dc.subject1302 Curriculum and Pedagogy
dc.subjectSport Sciences
dc.subject4201 Allied health and rehabilitation science
dc.subject4207 Sports science and exercise
dc.subject.meshHumans
dc.subject.meshMuscle, Skeletal
dc.subject.meshResistance Training
dc.subject.meshMuscle Strength
dc.subject.meshHypertrophy
dc.subject.meshMuscle, Skeletal
dc.subject.meshHumans
dc.subject.meshHypertrophy
dc.subject.meshMuscle Strength
dc.subject.meshResistance Training
dc.subject.meshHumans
dc.subject.meshMuscle, Skeletal
dc.subject.meshResistance Training
dc.subject.meshMuscle Strength
dc.subject.meshHypertrophy
dc.titleInfluence of Resistance Training Proximity-to-Failure on Skeletal Muscle Hypertrophy: A Systematic Review With Meta-Analysis
dc.typeJournal Article
pubs.elements-id483601
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