Differential Expression of Novel Metabolic and Immunological Biomarkers in Oysters Challenged With a Virulent Strain of OsHV-1

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aut.relation.journalDevelopmental & Comparative Immunologyen_NZ
aut.researcherYoung, Timothy
dc.contributor.authorYoung, Ten_NZ
dc.contributor.authorKesarcodi-Watson, Aen_NZ
dc.contributor.authorAlfaro, ACen_NZ
dc.contributor.authorMerien, Fen_NZ
dc.contributor.authorNguyen, TVen_NZ
dc.contributor.authorMae, Hen_NZ
dc.contributor.authorLe, DVen_NZ
dc.contributor.authorVillas-Bôas, Sen_NZ
dc.date.accessioned2017-08-04T04:12:33Z
dc.date.available2017-08-04T04:12:33Z
dc.date.copyright2017-04en_NZ
dc.date.issued2017-04en_NZ
dc.description.abstractEarly lifestages of the Pacific oyster (Crassostrea gigas) are highly susceptible to infection by OsHV-1 μVar, but little information exists regarding metabolic or pathophysiological responses of larval hosts. Using a metabolomics approach, we identified a range of metabolic and immunological responses in oyster larvae exposed to OsHV-1 μVar; some of which have not previously been reported in molluscs. Multivariate analyses of entire metabolite profiles were able to separate infected from non-infected larvae. Correlation analysis revealed the presence of major perturbations in the underlying biochemical networks and secondary pathway analysis of functionally-related metabolites identified a number of prospective pathways differentially regulated in virus-exposed larvae. These results provide new insights into the pathogenic mechanisms of OsHV-1 infection in oyster larvae, which may be applied to develop disease mitigation strategies and/or as new phenotypic information for selective breeding programmes aiming to enhance viral resistance.
dc.identifier.citationDevelopmental & Comparative Immunology, 73, 229-245.
dc.identifier.doi10.1016/j.dci.2017.03.025en_NZ
dc.identifier.issn0145-305Xen_NZ
dc.identifier.urihttps://hdl.handle.net/10292/10722
dc.publisherElsevier
dc.relation.urihttp://www.sciencedirect.com/science/article/pii/S0145305X16304815?via%3Dihub
dc.rightsCopyright © 2017 Elsevier Ltd. All rights reserved. This is the author’s version of a work that was accepted for publication in (see Citation). Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. The definitive version was published in (see Citation). The original publication is available at (see Publisher's Version).
dc.rights.accessrightsOpenAccessen_NZ
dc.subjectAquaculture; Crassostrea gigas; Larvae; Metabolism; Metabolomics; Ostreid herpesvirus
dc.titleDifferential Expression of Novel Metabolic and Immunological Biomarkers in Oysters Challenged With a Virulent Strain of OsHV-1en_NZ
dc.typeJournal Article
pubs.elements-id278158
pubs.organisational-data/AUT
pubs.organisational-data/AUT/Health & Environmental Science
pubs.organisational-data/AUT/Health & Environmental Science/Applied Science
pubs.organisational-data/AUT/Health & Environmental Science/School of Science
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