Altered Structural Connectome of Children with Auditory Processing Disorder: A Diffusion MRI Study

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aut.relation.journalCerebral Cortex
aut.relation.startpagebhad075
dc.contributor.authorAlvand, Ashkan
dc.contributor.authorKuruvilla-Mathew, Abin
dc.contributor.authorRoberts, Reece P
dc.contributor.authorPedersen, Mangor
dc.contributor.authorKirk, Ian J
dc.contributor.authorPurdy, Suzanne C
dc.date.accessioned2023-06-19T03:58:44Z
dc.date.available2023-06-19T03:58:44Z
dc.date.issued2023-03-16
dc.description.abstractAuditory processing disorder (APD) is a listening impairment that some school-aged children may experience despite having normal peripheral hearing. Recent resting-state functional magnetic resonance imaging (MRI) has revealed an alteration in regional functional brain topology in children with APD. However, little is known about the structural organization in APD. We used diffusion MRI data to investigate the structural connectome of 58 children from 8 to 14 years old diagnosed with APD (n = 29) and children without hearing complaints (healthy controls, HC; n = 29). We investigated the rich-club organization and structural connection differences between groups. The APD group showed similar rich-club organization and edge-wise connection compared with the HC group. However, at the regional level, we observed increased average path length (APL) and betweenness centrality in the right inferior parietal lobule and inferior precentral gyrus, respectively, in the APD group. Only HCs demonstrated a positive association between APL and the listening-in-spatialized-noise-sentences task in the left orbital gyrus. In line with previous findings, the current results provide evidence for altered structural networks at the regional level in the APD group, suggesting the involvement of multimodal deficits and a role for structure-function alteration in the listening difficulties of children with APD.
dc.identifier.citationCerebral Cortex, ISSN: 1047-3211 (Print); 1460-2199 (Online), Oxford University Press, bhad075-. doi: 10.1093/cercor/bhad075
dc.identifier.doi10.1093/cercor/bhad075
dc.identifier.issn1047-3211
dc.identifier.issn1460-2199
dc.identifier.urihttps://hdl.handle.net/10292/16297
dc.languageeng
dc.publisherOxford University Press
dc.relation.urihttps://academic.oup.com/cercor/article/33/12/7727/7078817
dc.rights.accessrightsOpenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectauditory processing disorder
dc.subjectdiffusion MRI
dc.subjectgraph theory
dc.subjectrich-club
dc.subjectstructural connectivity
dc.subjectauditory processing disorder
dc.subjectdiffusion MRI
dc.subjectgraph theory
dc.subjectrich-club
dc.subjectstructural connectivity
dc.subject32 Biomedical and Clinical Sciences
dc.subject3202 Clinical Sciences
dc.subjectNeurosciences
dc.subjectPediatric
dc.subjectBiomedical Imaging
dc.subjectEar
dc.subject1109 Neurosciences
dc.subject1701 Psychology
dc.subject1702 Cognitive Sciences
dc.subjectExperimental Psychology
dc.subject3209 Neurosciences
dc.subject5202 Biological psychology
dc.subject5204 Cognitive and computational psychology
dc.titleAltered Structural Connectome of Children with Auditory Processing Disorder: A Diffusion MRI Study
dc.typeJournal Article
pubs.elements-id496751
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