Methods for Quantification of Cannabinoids: A Narrative Review
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Pourseyed Lazarjani, Masoumeh
Torres, Stephanie
Hooker, Thom
Fowlie, Chris
Young, Owen
Seyfoddin, Ali
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Springer Science and Business Media LLC
Abstract
BACKGROUND: Around 144 cannabinoids have been identified in cannabis plant, among them tetrahydrocannabinol (THC) and cannabidiol (CBD) are the most prominent ones. Because of the legal restrictions on cannabis in many countries, it is difficult to obtain standards to use in research; nonetheless, it is important to develop a cannabinoid quantification technique with pharmaceutical applications for quality control of future therapeutic cannabinoids. METHOD: To find relevant articles for this narrative review paper, a combination of keywords such as medicinal cannabis, analytical, quantification and cannabinoids were searched for in PubMed, EMBASE, MEDLINE, Google Scholar and Cochrane Library (Wiley) databases. RESULTS: The most common cannabinoid quantification techniques include gas chromatography (GC) and high-performance liquid chromatography (HPLC). GC is often used in conjunction with mass spectrometry (MS) or flame ionization detection (FID). The major advantage of GC is terpenes quantification however, for evaluating acidic cannabinoids it needs to be derivatised. The main advantage of HPLC is the ability to quantify both acidic and neutral forms of cannabinoids without derivatisation which is often with MS or ultraviolet (UV) detectors. CONCLUSION: Based on the information presented in this review, the ideal cannabinoid quantification method is HPLC- MS/MS for the cannabinoids.
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Analytical, CBD, Cannabinoids, Cannabis, Quantification, THC, 42 Health Sciences, 4208 Traditional, Complementary and Integrative Medicine, Drug Abuse (NIDA only), Substance Misuse, Natural Products, Endocannabinoid System Research, Therapeutic Cannabinoid Research, Cannabidiol Research, Complementary and Integrative Health, 3 Good Health and Well Being, 4208 Traditional, complementary and integrative medicine
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Journal of Cannabis Research, ISSN: 2522-5782 (Print); 2522-5782 (Online), Springer Science and Business Media LLC, 2(1), 35-. doi: 10.1186/s42238-020-00040-2
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Except where otherwise noted, this item's license is described as Creative Commons Attribution