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Physical Activity for Public Health in the 21st Century

aut.relation.endpage1489
aut.relation.issue4
aut.relation.journalNature Medicine
aut.relation.startpage1479
aut.relation.volume32
dc.contributor.authorSalvo, Deborah
dc.contributor.authorCrochemore-Silva, Inacio
dc.contributor.authorWendt, Andrea
dc.contributor.authorTarp, Jakob
dc.contributor.authorShiroma, Eric J
dc.contributor.authorSimpson, Richard J
dc.contributor.authorLee, I-Min
dc.contributor.authorEkelund, Ulf
dc.contributor.authorCerin, Ester
dc.contributor.authorKeita, Youssouf
dc.contributor.authorBauman, Adrian
dc.contributor.authorHallal, Pedro C
dc.contributor.authorRamirez Varela, Andrea
dc.contributor.authorPratt, Michael
dc.contributor.authorReis, Rodrigo
dc.contributor.authorHinckson, Erica
dc.contributor.authorDing, Ding
dc.contributor.authorKohl, Harold W
dc.contributor.authorSallis, James
dc.date.accessioned2026-05-18T22:51:21Z
dc.date.available2026-05-18T22:51:21Z
dc.date.issued2026-03-09
dc.description.abstractWith over 5 million attributed deaths per year, physical inactivity is a major global public health issue. Although the importance of physical activity is well recognized within the scope of obesity and cardiometabolic disease prevention and control, its broader benefits for the health of individuals and societies are yet to be fully harnessed. Furthermore, the role of active leisure, active transport and active labor-primary domains of physical activity-in supporting or hindering social and health equity has been largely overlooked. Here we (1) used a health equity lens to describe global domain-specific physical activity inequalities through an analysis of World Health Organization STEPwise approach to NCD risk factor surveillance (WHO STEPS) data from 68 countries; (2) summarized evidence linking physical activity with health outcomes beyond cardiometabolic disease, including immunity and infectious disease, depression and cancer; and (3) developed a new model reconceptualizing physical activity to better respond to 21st-century public health challenges. Our global, intersectional analysis of gender and socioeconomic physical activity inequalities revealed a 40-percentage-point gap in active leisure-the only domain consistently driven by choice-between historically privileged groups (wealthy men in high-income countries) and historically disadvantaged ones (poor women in low-income countries). Robust evidence supports the benefits of physical activity for immunity and infectious disease, depression and cancer. Our reconceptualized model recognizes the influence of social identities, norms, policies and structures on physical activity for health and wellbeing and emphasizes the urgent need to develop and roll out policies and programs that disseminate and harness the full benefits of physical activity for human, societal and planetary health.
dc.identifier.citationNature Medicine, ISSN: 1078-8956 (Print); 1546-170X (Online), Nature Research, 32(4), 1479-1489. doi: 10.1038/s41591-026-04237-5
dc.identifier.doi10.1038/s41591-026-04237-5
dc.identifier.issn1078-8956
dc.identifier.issn1546-170X
dc.identifier.urihttp://hdl.handle.net/10292/21110
dc.languageeng
dc.publisherNature Research
dc.relation.urihttps://www.nature.com/articles/s41591-026-04237-5
dc.rightsOpen Access. This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.
dc.rights.accessrightsOpenAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject32 Biomedical and Clinical Sciences
dc.subject4206 Public Health
dc.subject42 Health Sciences
dc.subject3202 Clinical Sciences
dc.subjectPrevention
dc.subjectSocial Determinants of Health
dc.subjectHealth Disparities
dc.subjectBehavioral and Social Science
dc.subjectHealth Disparities and Racial or Ethnic Minority Health Research
dc.subjectPhysical Activity
dc.subjectBasic Behavioral and Social Science
dc.subjectClinical Research
dc.subject3.1 Primary prevention interventions to modify behaviours or promote wellbeing
dc.subjectCancer
dc.subjectCardiovascular
dc.subject3 Good Health and Well Being
dc.subject10 Reduced Inequalities
dc.subject11 Medical and Health Sciences
dc.subjectImmunology
dc.subject32 Biomedical and clinical sciences
dc.subject42 Health sciences
dc.subject.meshHumans
dc.subject.meshExercise
dc.subject.meshPublic Health
dc.subject.meshFemale
dc.subject.meshMale
dc.subject.meshSocioeconomic Factors
dc.subject.meshGlobal Health
dc.subject.meshRisk Factors
dc.subject.meshWorld Health Organization
dc.subject.meshHumans
dc.subject.meshExercise
dc.subject.meshRisk Factors
dc.subject.meshPublic Health
dc.subject.meshSocioeconomic Factors
dc.subject.meshWorld Health Organization
dc.subject.meshFemale
dc.subject.meshMale
dc.subject.meshGlobal Health
dc.subject.meshHumans
dc.subject.meshExercise
dc.subject.meshPublic Health
dc.subject.meshFemale
dc.subject.meshMale
dc.subject.meshSocioeconomic Factors
dc.subject.meshGlobal Health
dc.subject.meshRisk Factors
dc.subject.meshWorld Health Organization
dc.titlePhysical Activity for Public Health in the 21st Century
dc.typeJournal Article
pubs.elements-id756058

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