In Vitro and In Vivo Dendritic Cell Immune Stimulation Effect of Low Molecular Weight Fucoidan from New Zealand Undaria pinnatifida

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aut.relation.endpage197
aut.relation.issue3en_NZ
aut.relation.journalMarine Drugsen_NZ
aut.relation.startpage197
aut.relation.volume20en_NZ
aut.researcherLu, Jun
dc.contributor.authorLiu, Len_NZ
dc.contributor.authorYang, Xen_NZ
dc.contributor.authorYuan, Pen_NZ
dc.contributor.authorCai, Sen_NZ
dc.contributor.authorBao, Jen_NZ
dc.contributor.authorZhao, Yen_NZ
dc.contributor.authorAimaier, Aen_NZ
dc.contributor.authorAipire, Aen_NZ
dc.contributor.authorLu, Jen_NZ
dc.contributor.authorLi, Jen_NZ
dc.date.accessioned2022-03-21T03:16:20Z
dc.date.available2022-03-21T03:16:20Z
dc.description.abstractLow molecular weight fucoidan (LMWF) has been reported to have immunomodulation effects through the increase of the activation and function of macrophages. In this study, the regulating effect of LMWF from Undaria pinnatifida grown in New Zealand on dendritic cells (DCs) was investigated. We discovered that LMWF could stimulate DCs’ maturation and migration, as well as CD4+ and CD8+ T cells’ proliferation in vitro. We proved that this immune promoting activity is activated through TLR4 and its downstream MAPK and NF–κB signaling pathways. Further in vivo (mouse model) investigation showed that LMWF has a strong immunological boosting effect, such as facilitating the proliferation of immune cells and increasing the index of immune organs. These findings suggest that LMWF has a positive immunomodulatory effect and is a promising candidate to supplement cancer immunotherapy.en_NZ
dc.identifier.citationMarine Drugs, 20(3), 197. https://doi.org/10.3390/md20030197
dc.identifier.doi10.3390/md20030197en_NZ
dc.identifier.issn1660-3397en_NZ
dc.identifier.urihttps://hdl.handle.net/10292/15008
dc.languageenen_NZ
dc.publisherMDPI AGen_NZ
dc.relation.urihttps://www.mdpi.com/1660-3397/20/3/197
dc.rights© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
dc.rights.accessrightsOpenAccessen_NZ
dc.subjectLow molecular weight fucoidan (LMWF); Dendritic cells; Immune stimulation; Undaria pinnatifida; New Zealand
dc.titleIn Vitro and In Vivo Dendritic Cell Immune Stimulation Effect of Low Molecular Weight Fucoidan from New Zealand Undaria pinnatifidaen_NZ
dc.typeJournal Article
pubs.elements-id451785
pubs.organisational-data/AUT
pubs.organisational-data/AUT/Faculty of Health & Environmental Science
pubs.organisational-data/AUT/Faculty of Health & Environmental Science/School of Public Health & Interdisciplinary Studies
pubs.organisational-data/AUT/Faculty of Health & Environmental Science/School of Public Health & Interdisciplinary Studies/Biosciences Department
pubs.organisational-data/AUT/PBRF
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences/HI Interprofessional 2018 PBRF
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