Variability of serum markers of erythropoiesis during 6 days of racing in highly trained cyclists

Simple item page
aut.researcherHopkins, William Gary
dc.contributor.authorVoss, SC
dc.contributor.authorAlsayrafi, M
dc.contributor.authorBourdon, PC
dc.contributor.authorKlodt, F
dc.contributor.authorNonis, D
dc.contributor.authorHopkins, WG
dc.contributor.authorSchumacher, YO
dc.date.accessioned2013-10-08T23:00:59Z
dc.date.available2013-10-08T23:00:59Z
dc.date.copyright2013
dc.date.issued2013
dc.description.abstractThe athlete biological passport for the fight against doping is currently based on longitudinal monitoring for abnormal changes in cellular blood parameters. Serum parameters related to altered erythropoiesis could be considered for inclusion in the passport. The aim of this study was to quantify the changes in such parameters in athletes during a period of intense exercise. 12 highly trained cyclists tapered for 3 days before 6 days of simulated intense stage racing. Morning and afternoon blood samples were taken on most days and analysed for total protein, albumin, soluble transferrin receptor and ferritin concentrations. Plasma volume was determined via total haemoglobin mass measured by carbon-monoxide rebreathing. Percent changes in means from baseline and percent standard errors of measurement (analytical error plus intra-athlete variation) on each measurement occasion were estimated with mixed linear modelling of log-transformed measures. Means of all variables changed substantially in the days following the onset of racing, ranging from −13% (haemoglobin concentration) to +27% (ferritin). After the second day, errors of measurement were generally twice those at baseline. Plasma variables were affected by heavy exercise, either because of changes in plasma volume (total protein, albumin, haemoglobin), acute phase/inflammatory reactions (ferritin) or both (soluble transferrin receptor). These effects need to be taken into consideration when integrating a plasma parameter into the biological passport model for athletes.
dc.identifier.citationInternational Journal of Sports Medicine; 35(02): 89-94
dc.identifier.doi10.1055/s-0033-1345177
dc.identifier.issn0172-4622
dc.identifier.issn1439-3964
dc.identifier.urihttps://hdl.handle.net/10292/5737
dc.relation.urihttp://dx.doi.org/10.1055/s-0033-1345177
dc.rightsLike all Thieme subscription journals, SYNLETT also offers you the possibility to publish your work open access. Open access articles are available freely to read, download, print out and share, immediately and permanently: readers have access to your research independently of their libraries' journal collection.
dc.rights.accessrightsOpenAccess
dc.subjectDoping
dc.subjectEPO
dc.subjectBlood
dc.subjectSera
dc.subjectPlasma volume
dc.subjectsTfR
dc.titleVariability of serum markers of erythropoiesis during 6 days of racing in highly trained cyclists
dc.typeJournal Article
pubs.elements-id150402
pubs.organisational-data/AUT
pubs.organisational-data/AUT/Health & Environmental Science
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
hopkins.pdf
Size:
273.18 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
licence.htm
Size:
30.34 KB
Format:
Unknown data format
Description:
Download
Collections
School of Sport and Recreation