Antioxidant and Cytotoxicity Activities of Butylated Hydroxytoluene Ligands Capped Gold Nanoparticles

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aut.relation.endpage419
aut.relation.issue2en_NZ
aut.relation.journalChiang Mai Journal of Scienceen_NZ
aut.relation.startpage405
aut.relation.volume48en_NZ
aut.researcherDrabsch, Julie
dc.contributor.authorAhmad, MHen_NZ
dc.contributor.authorYehye, WAen_NZ
dc.contributor.authorRahman, NAen_NZ
dc.contributor.authorAl-Ani, LAen_NZ
dc.contributor.authorJohan, Men_NZ
dc.contributor.authorLu, Jen_NZ
dc.contributor.authorHashim, NMen_NZ
dc.date.accessioned2022-06-14T03:01:37Z
dc.date.available2022-06-14T03:01:37Z
dc.date.copyright2021en_NZ
dc.date.issued2021en_NZ
dc.description.abstractThe new potent nano-antioxidant of sulfur-containing butylated hydroxytoluene ligands (S-BHTLs)-conjugated with gold nanoparticles, Au-S-BHTLs, was synthesized by a conjugation of sulfur-containing ligands derived from BHT on the surface of gold nanoparticles (AuNPs). The in-house developing eight sulfur-containing BHT-ligands (S-BHTLs) were used for further study on functionalization with AuNPs and their biological activities. The antioxidant and cytotoxic abilities of eight types of Au-S-BHTLs such as compound Au-2a, Au-2b, Au-3a, Au-3b, Au-4a, Au-4b, Au-5a and Au-5b were tested by DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging and MTT assays against HT29 (human colorectal adenocarcinoma) and MCF7 (human breast adenocarcinoma). Based on the results, it was revealed that nanocomposites Au-5a and Au-3a attained over 50% lower IC values against free radical than the un-functionalized AuNPs. Meanwhile, nanocomposite Au-2b showed the highest cytotoxicity effect against both cancer cell lines. Selectivity and safety towards non-tumorgenic cell lines were also evaluated and proved superior selectivity index (SI) of all nanocomposites (SI > 2.00) against both cancer cells except Au-5b (SI = 1.87) against MCF7. Hence, the functionalization of S-BHTLs with gold nanoparticles has increased the selectivity of nanocomposites and enhanced the antioxidant potentials to become useful and promising anticancer agents. • 50en_NZ
dc.identifier.citationChiang Mai Journal of Science, 2021; 48(2) : 405-419
dc.identifier.issn0125-2526en_NZ
dc.identifier.urihttps://hdl.handle.net/10292/15221
dc.publisherChiang Mai Journal of Science
dc.relation.urihttps://epg.science.cmu.ac.th/ejournal/journalDetail.php?journal_id=11492en_NZ
dc.rightsThe Journal is published in open access electronic format only 6 times a year in January, March, May, July, September and November. As mentioned at the end of the EDITORIAL POLICY section, in order to cover processing costs and provide open access for articles which have been accepted, the Journal now charges a publication fee of USD350.
dc.rights.accessrightsOpenAccessen_NZ
dc.subjectGold nanoparticles; Au-S-BHTLs; DPPH; HT29; MCF7
dc.titleAntioxidant and Cytotoxicity Activities of Butylated Hydroxytoluene Ligands Capped Gold Nanoparticlesen_NZ
dc.typeJournal Article
pubs.elements-id430397
pubs.organisational-data/AUT
pubs.organisational-data/AUT/Faculty of Health & Environmental Science
pubs.organisational-data/AUT/Faculty of Health & Environmental Science/School of Public Health & Interdisciplinary Studies
pubs.organisational-data/AUT/Faculty of Health & Environmental Science/School of Public Health & Interdisciplinary Studies/Biosciences Department
pubs.organisational-data/AUT/PBRF
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences/HI Interprofessional 2018 PBRF
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