Induction of long-term depression-like plasticity by pairings of motor imagination and peripheral electrical stimulation

aut.researcherNiazi, Imran
dc.contributor.authorJochumsen, Men_NZ
dc.contributor.authorSignal, Nen_NZ
dc.contributor.authorNedergaard, RWen_NZ
dc.contributor.authorTaylor, Den_NZ
dc.contributor.authorHaavik, Hen_NZ
dc.contributor.authorNiazi, IKen_NZ
dc.date.accessioned2015-12-09T01:56:42Z
dc.date.available2015-12-09T01:56:42Z
dc.date.copyright2015-12-01en_NZ
dc.date.issued2015-12-01en_NZ
dc.description.abstractLong-term depression (LTD) and long-term potentiation (LTP)-like plasticity are models of synaptic plasticity which have been associated with memory and learning. The induction of LTD and LTP-like plasticity, using different stimulation protocols, has been proposed as a means of addressing abnormalities in cortical excitability associated with conditions such as focal hand dystonia and stroke. The aim of this study was to investigate whether the excitability of the cortical projections to the tibialis anterior (TA) muscle could be decreased when dorsiflexion of the ankle joint was imagined and paired with peripheral electrical stimulation (ES) of the nerve supplying the antagonist soleus muscle. The effect of stimulus timing was evaluated by comparing paired stimulation timed to reach the cortex before, at and after the onset of imagined movement. Fourteen healthy subjects participated in six experimental sessions held on non-consecutive days. The timing of stimulation delivery was determined offline based on the contingent negative variation (CNV) of electroencephalography brain data obtained during imagined dorsiflexion. Afferent stimulation was provided via a single pulse ES to the peripheral nerve paired, based on the CNV, with motor imagination of ankle dorsiflexion. A significant decrease (P = 0.001) in the excitability of the cortical projection of TA was observed when the afferent volley from the ES of the tibial nerve (TN) reached the cortex at the onset of motor imagination based on the CNV. When TN stimulation was delivered before (P = 0.62), or after (P = 0.23) imagined movement onset there was no significant effect. Nor was a significant effect found when ES of the TN was applied independent of imagined movement (P = 0.45). Therefore, the excitability of the cortical projection to a muscle can be inhibited when ES of the nerve supplying the antagonist muscle is precisely paired with the onset of imagined movement.
dc.identifier.citationFrontiers in Human Neuroscience. 9:644. doi: 10.3389/fnhum.2015.00644en_NZ
dc.identifier.doi10.3389/fnhum.2015.00644en_NZ
dc.identifier.issn1662-5161en_NZ
dc.identifier.urihttps://hdl.handle.net/10292/9303
dc.publisherFrontiers Media S.A.
dc.relation.urihttp://dx.doi.org/10.3389/fnhum.2015.00644
dc.rights© 2015 Jochumsen, Signal, Nedergaard, Taylor, Haavik and Niazi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
dc.rights.accessrightsOpenAccessen_NZ
dc.subjectLong-term depression; Long-term potentiation; Cortical excitability; Contingent negative variation; Brain plasticity; Associative stimulation; Motor imagination
dc.titleInduction of long-term depression-like plasticity by pairings of motor imagination and peripheral electrical stimulationen_NZ
dc.typeJournal Article
pubs.elements-id193862
pubs.organisational-data/AUT
pubs.organisational-data/AUT/Health & Environmental Science
Files
Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
LTD paper published version Frontiers.pdf
Size:
1.28 MB
Format:
Adobe Portable Document Format
Description:
License bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
RE4.10 Grant of Licence.docx
Size:
14.05 KB
Format:
Microsoft Word 2007+
Description: