The GDNF family: A role in cancer?

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aut.relation.endpage117
aut.relation.issue1en_NZ
aut.relation.journalNeoplasiaen_NZ
aut.relation.startpage99
aut.relation.volume20en_NZ
aut.researcherLiu, Dongxu
dc.contributor.authorFielder, GCen_NZ
dc.contributor.authorYang, TWSen_NZ
dc.contributor.authorRazdan, Men_NZ
dc.contributor.authorLi, Yen_NZ
dc.contributor.authorLu, Jen_NZ
dc.contributor.authorPerry, JKen_NZ
dc.contributor.authorLobie, PEen_NZ
dc.contributor.authorLiu, DXen_NZ
dc.date.accessioned2018-07-02T03:59:09Z
dc.date.available2018-07-02T03:59:09Z
dc.date.copyright2018en_NZ
dc.date.issued2018en_NZ
dc.description.abstractThe glial cell line–derived neurotrophic factor (GDNF) family of ligands (GFLs) comprising of GDNF, neurturin, artemin, and persephin plays an important role in the development and maintenance of the central and peripheral nervous system, renal morphogenesis, and spermatogenesis. Here we review our current understanding of GFL biology, and supported by recent progress in the area, we examine their emerging role in endocrine-related and other non–hormone-dependent solid neoplasms. The ability of GFLs to elicit actions that resemble those perturbed in an oncogenic phenotype, alongside mounting evidence of GFL involvement in tumor progression, presents novel opportunities for therapeutic intervention.en_NZ
dc.identifier.citationNeoplasia, Volume 20, Issue 1, Pages 99-117
dc.identifier.doi10.1016/j.neo.2017.10.010en_NZ
dc.identifier.issn1476-5586en_NZ
dc.identifier.urihttps://hdl.handle.net/10292/11634
dc.publisherEdiciones Doyma S.A.en_NZ
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730419/?report=classicen_NZ
dc.rights© 2018 The Authors. Published by Elsevier Inc. on behalf of Neoplasia Press, Inc. This is an open access article under theCCBY-NC-NDlicense (http://creativecommons.org/licenses/by-nc-nd/4.0/). 1476-5586
dc.rights.accessrightsOpenAccessen_NZ
dc.titleThe GDNF family: A role in cancer?en_NZ
dc.typeJournal Article
pubs.elements-id322438
pubs.organisational-data/AUT
pubs.organisational-data/AUT/Health & Environmental Science
pubs.organisational-data/AUT/Health & Environmental Science/Applied Science
pubs.organisational-data/AUT/Health & Environmental Science/Interprofessional Health
pubs.organisational-data/AUT/Health & Environmental Science/School of Science
pubs.organisational-data/AUT/PBRF
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences/HA Science 2018 PBRF
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences/HI Interprofessional 2018 PBRF
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