A Low-Carbohydrate Diet in Place of SGLT2i Therapy in a Patient with Diabetic Cardiomyopathy

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aut.relation.endpage86
aut.relation.issue4
aut.relation.journalEndocrinology, Diabetes and Metabolism Case Reports
aut.relation.startpage23
aut.relation.volume2023
dc.contributor.authorKleissl-Muir, S
dc.contributor.authorRasmussen, B
dc.contributor.authorOwen, A
dc.contributor.authorZinn, C
dc.contributor.authorDriscoll, A
dc.date.accessioned2024-01-14T21:07:45Z
dc.date.available2024-01-14T21:07:45Z
dc.date.issued2023-12-13
dc.description.abstractIn patients with diabetes mellitus, the toxic milieu caused by abnormal glucose and free fatty acid handling can lead to heart failure (HF). Referred to as diabetic cardiomyopathy (DMCM), this syndrome often exists in the absence of conventional risk factors for HF such as history of myocardial infarction or hypertension. Low-carbohydrate diets (LCDs) have recently been endorsed as an efficacious therapeutic dietary approach to prevent and reverse cardiometabolic disease including type 2 diabetes mellitus (T2DM). LCDs improve systemic insulin resistance (IR), reverses cardiac remodelling in a rodent model and downregulates the expression of sodium–glucose co-transporter 2 (SGLT2) receptors in the kidney. It is therefore conceivable that a lifestyle approach such as adopting an LCD can be offered to patients with DMCM. The reported case is that of a 45-year-old man with a 15-year history of non-ischaemic cardiomyopathy, T2DM and obesity. The patient volunteered to engage in a 16-week low-carbohydrate dietary intervention trial and then self-selected to remain on this diet for 1 year. The whole-food LCD was based on simple ‘traffic light’ style food lists and not designed to restrict calories, protein, fat or salt. After 1 year, the patient had lost 39 kg and his cardiometabolic markers had significantly improved. LCDs present a potentially beneficial approach for patients with DMCM and could be considered as a lifestyle intervention before SGLT2i therapy is commenced.
dc.identifier.citationEndocrinology, Diabetes and Metabolism Case Reports, ISSN: 2052-0573 (Print); 2052-0573 (Online), Bioscientifica, 2023(4), 23-86. doi: 10.1530/EDM-23-0086
dc.identifier.doi10.1530/EDM-23-0086
dc.identifier.issn2052-0573
dc.identifier.issn2052-0573
dc.identifier.urihttp://hdl.handle.net/10292/17095
dc.languageeng
dc.publisherBioscientifica
dc.relation.urihttps://edm.bioscientifica.com/view/journals/edm/2023/4/EDM23-0086.xml?body=contentsummary-62454
dc.rights© 2023 the author(s). This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
dc.rights.accessrightsOpenAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject32 Biomedical and Clinical Sciences
dc.subject3210 Nutrition and Dietetics
dc.subjectPrevention
dc.subjectDiabetes
dc.subjectCardiovascular
dc.subjectNutrition
dc.subjectClinical Research
dc.subjectObesity
dc.subjectHeart Disease
dc.subject5.1 Pharmaceuticals
dc.subject5 Development of treatments and therapeutic interventions
dc.subjectMetabolic and endocrine
dc.subjectCardiovascular
dc.subject3202 Clinical sciences
dc.subject3205 Medical biochemistry and metabolomics
dc.titleA Low-Carbohydrate Diet in Place of SGLT2i Therapy in a Patient with Diabetic Cardiomyopathy
dc.typeJournal Article
pubs.elements-id533253
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