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Antioxidant and Cytotoxicity Activities of Butylated Hydroxytoluene Ligands Capped Gold Nanoparticles

Ahmad, MH; Yehye, WA; Rahman, NA; Al-Ani, LA; Johan, M; Lu, J; Hashim, NM
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http://hdl.handle.net/10292/15221
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Abstract
The new potent nano-antioxidant of sulfur-containing butylated hydroxytoluene ligands (S-BHTLs)-conjugated with gold nanoparticles, Au-S-BHTLs, was synthesized by a conjugation of sulfur-containing ligands derived from BHT on the surface of gold nanoparticles (AuNPs). The in-house developing eight sulfur-containing BHT-ligands (S-BHTLs) were used for further study on functionalization with AuNPs and their biological activities. The antioxidant and cytotoxic abilities of eight types of Au-S-BHTLs such as compound Au-2a, Au-2b, Au-3a, Au-3b, Au-4a, Au-4b, Au-5a and Au-5b were tested by DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging and MTT assays against HT29 (human colorectal adenocarcinoma) and MCF7 (human breast adenocarcinoma). Based on the results, it was revealed that nanocomposites Au-5a and Au-3a attained over 50% lower IC values against free radical than the un-functionalized AuNPs. Meanwhile, nanocomposite Au-2b showed the highest cytotoxicity effect against both cancer cell lines. Selectivity and safety towards non-tumorgenic cell lines were also evaluated and proved superior selectivity index (SI) of all nanocomposites (SI > 2.00) against both cancer cells except Au-5b (SI = 1.87) against MCF7. Hence, the functionalization of S-BHTLs with gold nanoparticles has increased the selectivity of nanocomposites and enhanced the antioxidant potentials to become useful and promising anticancer agents. • 50
Keywords
Gold nanoparticles; Au-S-BHTLs; DPPH; HT29; MCF7
Date
2021
Source
Chiang Mai Journal of Science, 2021; 48(2) : 405-419
Item Type
Journal Article
Publisher
Chiang Mai Journal of Science
Publisher's Version
https://epg.science.cmu.ac.th/ejournal/journalDetail.php?journal_id=11492
Rights Statement
The Journal is published in open access electronic format only 6 times a year in January, March, May, July, September and November. As mentioned at the end of the EDITORIAL POLICY section, in order to cover processing costs and provide open access for articles which have been accepted, the Journal now charges a publication fee of USD350.

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