Nanoantioxidants: Recent Trends in Antioxidant Delivery Applications

Date
2020
Authors
Khalil, I
Yehye, WA
Etxeberria, AE
Alhadi, AA
Dezfooli, SM
Julkapli, NBM
Basirun, WJ
Seyfoddin, A
Supervisor
Item type
Journal Article
Degree name
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI AG
Abstract

Antioxidants interact with free radicals, terminating the adverse chain reactions and converting them to harmless products. Antioxidants thus minimize the oxidative stress and play a crucial role in the treatment of free radicals-induced diseases. However, the effectiveness of natural and/or synthetic antioxidants is limited due to their poor absorption, difficulties to cross the cell membranes, and degradation during delivery, hence contributing to their limited bioavailability. To address these issues, antioxidants covalently linked with nanoparticles, entrapped in nanogel, hollow particles, or encapsulated into nanoparticles of diverse origin have been used to provide better stability, gradual and sustained release, biocompatibility, and targeted delivery of the antioxidants with superior antioxidant profiles. This review aims to critically evaluate the recent scientific evaluations of nanoparticles as the antioxidant delivery vehicles, as well as their contribution in efficient and enhanced antioxidant activities.

Description
Keywords
Antioxidant; Nanoparticles; Nanoantioxidant; Antioxidant delivery; Nanocarrier; Nanoencapsulation
Source
Antioxidants, 9(1), 24.
Rights statement
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.