Pairing Voluntary Movement and Muscle-located Electrical Stimulation Increases Cortical Excitability

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aut.relation.issue482en_NZ
aut.relation.journalFrontiers in Human Neuroscienceen_NZ
aut.relation.volume10en_NZ
aut.researcherNiazi, Imran
dc.contributor.authorJochumsen, Men_NZ
dc.contributor.authorNiazi, Ien_NZ
dc.contributor.authorSignal, Nen_NZ
dc.contributor.authorNedergaard, RWen_NZ
dc.contributor.authorHolt, Ken_NZ
dc.contributor.authorHaavik, Hen_NZ
dc.contributor.authorTaylor, Den_NZ
dc.date.accessioned2017-07-11T04:03:32Z
dc.date.available2017-07-11T04:03:32Z
dc.date.copyright2016-09-28en_NZ
dc.date.issued2016-09-28en_NZ
dc.description.abstractLearning new motor skills has been correlated with increased cortical excitability. In this study, different location of electrical stimulation (ES), nerve, or muscle, was paired with voluntary movement to investigate if ES paired with voluntary movement (a) would increase the excitability of cortical projections to tibialis anterior and (b) if stimulation location mattered. Cortical excitability changes were quantified using motor evoked potentials (MEPs) elicited by transcranial magnetic stimulation (TMS) at varying intensities during four conditions. Twelve healthy subjects performed 50 dorsiflexions at the ankle during nerve or muscle ES at motor threshold (MTh). ES alone was delivered 50 times and the movement was performed 50 times. A significant increase in the excitability from pre- to post-intervention (P = 0.0061) and pre- to 30 min post-intervention (P = 0.017) measurements was observed when voluntary movement was paired with muscle ES located at tibialis anterior. An increase of 50 ± 57 and 28 ± 54% in the maximum MEPs was obtained for voluntary movement paired with muscle-located and nerve-located ES, respectively. The maximum MEPs for voluntary movement alone and muscle-located ES alone were −5 ± 28 and 2 ± 42%, respectively. Pairing voluntary movement with muscle-located ES increases excitability of corticospinal projections of tibialis anterior in healthy participants. This finding suggests that active participation during muscle-located ES protocols increases cortical excitability to a greater extent than stimulation alone. The next stage of this research is to investigate the effect in people with stroke. The results may have implications for motor recovery in patients with motor impairments following neurological injury.
dc.identifier.citationFrontiers in Human Neuroscience. doi: 10:482. doi: 10.3389/fnhum.2016.00482
dc.identifier.doi10.3389/fnhum.2016.00482en_NZ
dc.identifier.issn1662-5161en_NZ
dc.identifier.urihttps://hdl.handle.net/10292/10652
dc.publisherFrontiers Media S.A
dc.relation.urihttp://journal.frontiersin.org/article/10.3389/fnhum.2016.00482/fullen_NZ
dc.rights© 2016 Jochumsen, Niazi, Signal, Nedergaard, Holt, Haavik and Taylor. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
dc.rights.accessrightsOpenAccessen_NZ
dc.subjectElectrical stimulation; Motor cortical activation; Transcranial magnetic stimulation; Motor evoked potentials; Corticospinal excitability; Neuronal plasticity; Long-term potentiation
dc.titlePairing Voluntary Movement and Muscle-located Electrical Stimulation Increases Cortical Excitabilityen_NZ
dc.typeJournal Article
pubs.elements-id194116
pubs.organisational-data/AUT
pubs.organisational-data/AUT/Health & Environmental Science
pubs.organisational-data/AUT/Health & Environmental Science/Clinical Sciences
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