Collaborative European Neurotrauma Effectiveness Research in Traumatic Brain Injury (Center-tbi): A Prospective Longitudinal Observational Study

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aut.relation.endpage80
aut.relation.issue1en_NZ
aut.relation.journalNeurosurgeryen_NZ
aut.relation.startpage67
aut.relation.volume76en_NZ
aut.researcherTheadom, Alice
dc.contributor.authorTheadom, Aen_NZ
dc.contributor.authorMaas, AIRen_NZ
dc.contributor.authorMenon, Den_NZ
dc.contributor.authorSteyerberg, EWen_NZ
dc.contributor.authorCiterio, Gen_NZ
dc.contributor.authorLecky, Fen_NZ
dc.contributor.authorManley, GTen_NZ
dc.contributor.authorHill, Sen_NZ
dc.contributor.authorLegrand, Ven_NZ
dc.contributor.authorSorgner, Aen_NZ
dc.contributor.authorOn behalf of the CENTER-TBI participants and, Ien_NZ
dc.date.accessioned2016-10-07T03:06:12Z
dc.date.available2016-10-07T03:06:12Z
dc.date.copyright2015en_NZ
dc.date.issued2015en_NZ
dc.description.abstractBACKGROUND: Current classification of traumatic brain injury (TBI) is suboptimal, and management is based on weak evidence, with little attempt to personalize treatment. A need exists for new precision medicine and stratified management approaches that incorporate emerging technologies. OBJECTIVE: To improve characterization and classification of TBI and to identify best clinical care, using comparative effectiveness research approaches. METHODS: This multicenter, longitudinal, prospective, observational study in 22 countries across Europe and Israel will collect detailed data from 5400 consenting patients, presenting within 24 hours of injury, with a clinical diagnosis of TBI and an indication for computed tomography. Broader registry-level data collection in approximately 20 000 patients will assess generalizability. Cross sectional comprehensive outcome assessments, including quality of life and neuropsychological testing, will be performed at 6 months. Longitudinal assessments will continue up to 24 months post TBI in patient subsets. Advanced neuroimaging and genomic and biomarker data will be used to improve characterization, and analyses will include neuroinformatics approaches to address variations in process and clinical care. Results will be integrated with living systematic reviews in a process of knowledge transfer. The study initiation was from October to December 2014, and the recruitment period was for 18 to 24 months. EXPECTED OUTCOMES: Collaborative European NeuroTrauma Effectiveness Research in TBI should provide novel multidimensional approaches to TBI characterization and classification, evidence to support treatment recommendations, and benchmarks for quality of care. Data and sample repositories will ensure opportunities for legacy research. DISCUSSION: Comparative effectiveness research provides an alternative to reductionistic clinical trials in restricted patient populations by exploiting differences in biology, care, and outcome to support optimal personalized patient management.
dc.identifier.citationNeurosurgery. January 2015 - Volume 76 - Issue 1 - p 67–80
dc.identifier.doi10.1227/NEU.0000000000000575
dc.identifier.issn1524-4040en_NZ
dc.identifier.urihttps://hdl.handle.net/10292/10068
dc.publisherCongress of Neurological Surgeons
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.
dc.rights.accessrightsOpenAccessen_NZ
dc.subjectClinical study; Comparative effectiveness research; Protocol; Traumatic brain injury
dc.titleCollaborative European Neurotrauma Effectiveness Research in Traumatic Brain Injury (Center-tbi): A Prospective Longitudinal Observational Studyen_NZ
dc.typeJournal Article
pubs.elements-id185712
pubs.organisational-data/AUT
pubs.organisational-data/AUT/Health & Environmental Science
pubs.organisational-data/AUT/Health & Environmental Science/Clinical Sciences
pubs.organisational-data/AUT/Health & Environmental Science/Health Faculty Office
pubs.organisational-data/AUT/Health & Environmental Science/Nursing
pubs.organisational-data/AUT/Health & Environmental Science/Public Health & Psych Studies
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