A Pilot Study Examining the Dielectric Response of Human Forearm Tissues

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aut.relation.endpage961
aut.relation.issue11
aut.relation.journalBiosensors
aut.relation.startpage961
aut.relation.volume13
dc.contributor.authorYu, Yang
dc.contributor.authorKalra, Anubha Manju
dc.contributor.authorAnand, Gautam
dc.contributor.authorLowe, Andrew
dc.date.accessioned2023-11-08T23:27:11Z
dc.date.available2023-11-08T23:27:11Z
dc.date.issued2023-10-29
dc.description.abstractThis work aims to describe the dielectric behaviors of four main tissues in the human forearm using mathematical modelling, including fat, muscle, blood and bone. Multi-frequency bioimpedance analysis (MF-BIA) was initially performed using the finite element method (FEM) with a 3D forearm model to estimate impedance spectra from 10 kHz to 1 MHz, followed by a pilot study involving two healthy subjects to characterize the response of actual forearm tissues from 1 kHz to 349 kHz. Both the simulation and experimental results were fitted to a single-dispersion Cole model (SDCM) and a multi-dispersion Cole model (MDCM) to determine the Cole parameters for each tissue. Cole-type responses of both simulated and actual human forearms were observed. A paired t-test based on the root mean squared error (RMSE) values indicated that both Cole models performed comparably in fitting both simulated and measured bioimpedance data. However, MDCM exhibited higher accuracy, with a correlation coefficient (R2) of 0.99 and 0.89, RMSE of 0.22 Ω and 0.56 Ω, mean difference (mean ± standard deviation) of 0.00 ± 0.23 Ω and −0.28 ± 0.23 Ω, and mean absolute error (MAE) of 0.0007 Ω and 0.2789 Ω for the real part and imaginary part of impedance, respectively. Determining the electrical response of multi-tissues can be helpful in developing physiological monitoring of an organ or a section of the human body through MF-BIA and hemodynamic monitoring by filtering out the impedance contributions from the surrounding tissues to blood-flow-induced impedance variations.
dc.identifier.citationBiosensors, ISSN: 2079-6374 (Print); 2079-6374 (Online), MDPI AG, 13(11), 961-961. doi: 10.3390/bios13110961
dc.identifier.doi10.3390/bios13110961
dc.identifier.issn2079-6374
dc.identifier.issn2079-6374
dc.identifier.urihttp://hdl.handle.net/10292/16898
dc.languageen
dc.publisherMDPI AG
dc.relation.urihttps://www.mdpi.com/2079-6374/13/11/961
dc.rights.accessrightsOpenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject0301 Analytical Chemistry
dc.subject0601 Biochemistry and Cell Biology
dc.subject3101 Biochemistry and cell biology
dc.subject3401 Analytical chemistry
dc.titleA Pilot Study Examining the Dielectric Response of Human Forearm Tissues
dc.typeJournal Article
pubs.elements-id528041
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