Natural History of Falls in an Incident Cohort of Parkinson’s Disease: Early Evolution, Risk and Protective Features

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aut.relation.issue11en_NZ
aut.relation.journalJournal of Neurologyen_NZ
aut.relation.volume264en_NZ
aut.researcherLord, Sue
dc.contributor.authorLord, Sen_NZ
dc.contributor.authorGalna, Ben_NZ
dc.contributor.authorYarnall, AJen_NZ
dc.contributor.authorMorris, Ren_NZ
dc.contributor.authorColeman, Sen_NZ
dc.contributor.authorBurn, Den_NZ
dc.contributor.authorRochester, Len_NZ
dc.date.accessioned2018-12-10T01:55:49Z
dc.date.available2018-12-10T01:55:49Z
dc.date.copyright2017en_NZ
dc.date.issued2017en_NZ
dc.description.abstractThe natural history of falls in early Parkinson’s disease (PD) is poorly understood despite the profound effect of falls on outcome. The primary aim of this study was to describe the natural history of falls, and characterise fallers over 54 months in 99 newly diagnosed people with PD. Seventy-nine (79.7%) participants fell over 54 months and 20 (20.3%) remained falls-naïve. Twenty six (26.2%) reported retrospective falls at baseline. Gait outcomes, disease severity and self-efficacy significantly discriminated across groups. Subjective cognitive complaints emerged as the only significant cognitive predictor. Without exception, outcomes were better for non-fallers compared with fallers at any time point. Between group differences for 54 month fallers and non-fallers were influenced by the inclusi on of retrospective fallers and showed a broader range of discriminant characteristics, notably stance time variability and balance self-efficacy. Single fallers (n = 7) were significantly younger than recurrent fallers (n = 58) by almost 15 years (P = 0.013). Baseline performance in early PD discriminates fallers over 54 months, thereby identifying those at risk of falls. Clinical profiles for established and emergent fallers are to some extent distinct. These results reiterate the need for timely interventions to improve postural control and gait.en_NZ
dc.identifier.citationJournal of Neurology, 264(11), pp. 2268-2276.
dc.identifier.doi10.1007/s00415-017-8620-yen_NZ
dc.identifier.issn0340-5354en_NZ
dc.identifier.issn1432-1459en_NZ
dc.identifier.urihttp://hdl.handle.net/10292/12107
dc.publisherSpringer
dc.relation.urihttps://link.springer.com/article/10.1007%2Fs00415-017-8620-y#copyrightInformation
dc.rightsThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
dc.rights.accessrightsOpenAccessen_NZ
dc.subjectParkinson’s disease; Falls; Prognosis; Characteristics
dc.titleNatural History of Falls in an Incident Cohort of Parkinson’s Disease: Early Evolution, Risk and Protective Featuresen_NZ
dc.typeJournal Article
pubs.elements-id314468
pubs.organisational-data/AUT
pubs.organisational-data/AUT/Health & Environmental Science
pubs.organisational-data/AUT/Health & Environmental Science/Clinical Sciences
pubs.organisational-data/AUT/PBRF
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences/HH Clinical Sciences 2018 PBRF
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