Assessing the Test–retest Repeatability of Insulin Resistance Measures: Homeostasis Model Assessment 2 and Oral Glucose Insulin Sensitivity

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aut.relation.issue1en_NZ
aut.relation.journalJournal of Insulin Resistanceen_NZ
aut.relation.volume2en_NZ
aut.researcherCrofts, Catherine
dc.contributor.authorCrofts, Cen_NZ
dc.contributor.authorWheldon, MCen_NZ
dc.contributor.authorZinn, Cen_NZ
dc.contributor.authorLan-Pidhainy, X-Men_NZ
dc.contributor.authorWolever, Ten_NZ
dc.contributor.authorSchofield, Gen_NZ
dc.date.accessioned2017-11-03T00:23:19Z
dc.date.available2017-11-03T00:23:19Z
dc.date.copyright2017en_NZ
dc.date.issued2017en_NZ
dc.description.abstractBackground: Insulin resistance is commonly assessed using the homeostasis model assessment (HOMA) variants. HOMA is potentially insensitive to change because of its high coefficient of variation. The repeatability coefficient is an alternative means of assessing test repeatability. To be confident of clinical change, rather than biological variation, a subsequent test needs to differ from the former by more than the repeatability coefficient using the equation. Test 1 = Test 2 ± repeatability coefficient. The repeatability coefficients for measures of insulin resistance are unknown. Aim: To compare the repeatability coefficient of HOMA2 variants (Beta-cell function [%B], insulin sensitivity [%S], insulin resistance [IR]) to a dynamic measure of insulin resistance, and the oral glucose insulin sensitivity (OGIS) test. Setting: The raw data from a previously used data set were reanalysed. Methods: Glycaemic and insulinaemic tests were performed on 32 men and women both with (n = 10) and without type 2 diabetes (n = 22). From these data, eight fasting tests and three 50-g oral glucose tolerance tests were used to calculate HOMA2 and OGIS. The methods of Bland and Altman assessed repeatability. Results: Repeatability coefficients for all participants for the HOMA2 %B, %S and IR variants were 72.91, 189.75 and 0.9, which equates to 89%, 135% and 89% of their respective grand means. By contrast, OGIS had a repeatability coefficient of 87.13, which equates to 21% of the grand mean. Conclusion: Because of the high repeatability coefficient relative to the grand mean, use of HOMA2 measures for assessing insulin resistance in small population studies should be reconsidered.
dc.identifier.citationJournal of Insulin Resistance; Vol 2, No 1 (2017)
dc.identifier.doi10.4102/jir.v2i1.27en_NZ
dc.identifier.urihttps://hdl.handle.net/10292/10939
dc.publisherAfrican Online Scientific Information Systems (AOSIS)
dc.relation.urihttp://www.insulinresistance.org/index.php/jir/article/view/27en_NZ
dc.rightsAll articles published in this journal are licensed under the Creative Commons Attribution 4.0 International (CC BY 4.0) license, unless otherwise stated.
dc.rights.accessrightsOpenAccessen_NZ
dc.subjectHOMA; Insulin resistance; OGIS; Repeatability
dc.titleAssessing the Test–retest Repeatability of Insulin Resistance Measures: Homeostasis Model Assessment 2 and Oral Glucose Insulin Sensitivityen_NZ
dc.typeJournal Article
pubs.elements-id316659
pubs.organisational-data/AUT
pubs.organisational-data/AUT/Health & Environmental Science
pubs.organisational-data/AUT/Health & Environmental Science/Interprofessional Health
pubs.organisational-data/AUT/PBRF
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences/HI Interprofessional 2018 PBRF
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