Model Demonstrates Functional Purpose of the Nasal Cycle

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aut.relation.articlenumber38en_NZ
aut.relation.journalBioMedical Engineering Onlineen_NZ
aut.relation.volume14en_NZ
aut.researcherWhite, David
dc.contributor.authorWhite, DEen_NZ
dc.contributor.authorBartley, Jen_NZ
dc.contributor.authorNates, RJen_NZ
dc.date.accessioned2020-03-02T22:30:58Z
dc.date.available2020-03-02T22:30:58Z
dc.date.copyright2015en_NZ
dc.date.issued2015en_NZ
dc.description.abstractBackground: Despite the occurrence of the nasal cycle being well documented, the functional purpose of this phenomenon is not well understood. This investigation seeks to better understand the physiological objective of the nasal cycle in terms of airway health through the use of a computational nasal air-conditioning model. Method: A new state-variable heat and water mass transfer model is developed to predict airway surface liquid (ASL) hydration status within each nasal airway. Nasal geometry, based on in-vivo magnetic resonance imaging (MRI) data is used to apportion inter-nasal air flow. Results: The results demonstrate that the airway conducting the majority of the airflow also experiences a degree of ASL dehydration, as a consequence of undertaking the bulk of the heat and water mass transfer duties. In contrast, the reduced air conditioning demand within the other airway allows its ASL layer to remain sufficiently hydrated so as to support continuous mucociliary clearance. Conclusions: It is quantitatively demonstrated in this work how the nasal cycle enables the upper airway to accommodate the contrasting roles of air conditioning and the removal of entrapped contaminants through fluctuation in airflow partitioning between each airway.en_NZ
dc.identifier.citationBiomedical Engineering Online, 14(1), 38.
dc.identifier.doi10.1186/s12938-015-0034-4en_NZ
dc.identifier.issn1475-925Xen_NZ
dc.identifier.urihttps://hdl.handle.net/10292/13173
dc.languageengen_NZ
dc.publisherBioMed Central Ltd.en_NZ
dc.relation.urihttps://biomedical-engineering-online.biomedcentral.com/articles/10.1186/s12938-015-0034-4
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
dc.rights.accessrightsOpenAccessen_NZ
dc.subjectAir-conditioning modelen_NZ
dc.subjectAirflow partitioningen_NZ
dc.subjectAirway surface liquiden_NZ
dc.subjectMucociliary transporten_NZ
dc.subjectNasal cycleen_NZ
dc.titleModel Demonstrates Functional Purpose of the Nasal Cycleen_NZ
dc.typeJournal Article
pubs.elements-id182821
pubs.organisational-data/AUT
pubs.organisational-data/AUT/Design & Creative Technologies
pubs.organisational-data/AUT/Design & Creative Technologies/Engineering, Computer & Mathematical Sciences
pubs.organisational-data/AUT/PBRF
pubs.organisational-data/AUT/PBRF/PBRF Design and Creative Technologies
pubs.organisational-data/AUT/PBRF/PBRF Design and Creative Technologies/PBRF ECMS
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