Serum Metabolome Associated With Severity of Acute Traumatic Brain Injury

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aut.relation.issue1en_NZ
aut.relation.journalNature Communicationsen_NZ
aut.relation.volume13en_NZ
aut.researcherJones, Kelly
dc.contributor.authorThomas, Ien_NZ
dc.contributor.authorDickens, AMen_NZ
dc.contributor.authorPosti, JPen_NZ
dc.contributor.authorCzeiter, Een_NZ
dc.contributor.authorDuberg, Den_NZ
dc.contributor.authorSinioja, Ten_NZ
dc.contributor.authorKråkström, Men_NZ
dc.contributor.authorRetel Helmrich, IRAen_NZ
dc.contributor.authorWang, KKWen_NZ
dc.contributor.authorMaas, AIRen_NZ
dc.contributor.authorSteyerberg, EWen_NZ
dc.contributor.authorMenon, DKen_NZ
dc.contributor.authorTenovuo, Oen_NZ
dc.contributor.authorHyötyläinen, Ten_NZ
dc.contributor.authorBüki, Aen_NZ
dc.contributor.authorOrešič, Men_NZ
dc.contributor.authorÅkerlund, Cen_NZ
dc.contributor.authorAmrein, Ken_NZ
dc.contributor.authorAndelic, Nen_NZ
dc.contributor.authorAndreassen, Len_NZ
dc.contributor.authorAnke, Aen_NZ
dc.contributor.authorAntoni, Aen_NZ
dc.contributor.authorAudibert, Gen_NZ
dc.contributor.authorAzouvi, Pen_NZ
dc.contributor.authorAzzolini, MLen_NZ
dc.contributor.authorBartels, Ren_NZ
dc.contributor.authorBarzó, Pen_NZ
dc.contributor.authorBeauvais, Ren_NZ
dc.contributor.authorBeer, Ren_NZ
dc.contributor.authorBellander, BMen_NZ
dc.contributor.authorBelli, Aen_NZ
dc.contributor.authorBenali, Hen_NZ
dc.contributor.authorBerardino, Men_NZ
dc.contributor.authorBeretta, Len_NZ
dc.contributor.authorBlaabjerg, Men_NZ
dc.contributor.authorBragge, Pen_NZ
dc.contributor.authorBrazinova, Aen_NZ
dc.contributor.authorBrinck, Ven_NZ
dc.contributor.authorBrooker, Jen_NZ
dc.contributor.authorBrorsson, Cen_NZ
dc.contributor.authorBullinger, Men_NZ
dc.contributor.authorCabeleira, Men_NZ
dc.contributor.authorCaccioppola, Aen_NZ
dc.contributor.authorCalappi, Een_NZ
dc.contributor.authorCalvi, MRen_NZ
dc.contributor.authorCameron, Pen_NZ
dc.contributor.authorLozano, GCen_NZ
dc.contributor.authorCarbonara, Men_NZ
dc.contributor.authorCavallo, Sen_NZ
dc.contributor.authorChevallard, Gen_NZ
dc.contributor.authorChieregato, Aen_NZ
dc.contributor.authorCiterio, Gen_NZ
dc.contributor.authorClusmann, Hen_NZ
dc.contributor.authorCoburn, Men_NZ
dc.contributor.authorColes, Jen_NZ
dc.contributor.authorCooper, JDen_NZ
dc.contributor.authorCorreia, Men_NZ
dc.contributor.authorČović, Aen_NZ
dc.contributor.authorCurry, Nen_NZ
dc.contributor.authorCzosnyka, Men_NZ
dc.contributor.authorDahyot-Fizelier, Cen_NZ
dc.contributor.authorDark, Pen_NZ
dc.contributor.authorDawes, Hen_NZ
dc.contributor.authorDe Keyser, Ven_NZ
dc.contributor.authorDegos, Ven_NZ
dc.contributor.authorCorte, FDen_NZ
dc.contributor.authorden Boogert, Hen_NZ
dc.contributor.authorDepreitere, Ben_NZ
dc.contributor.authorĐilvesi, Đen_NZ
dc.contributor.authorDixit, Aen_NZ
dc.contributor.authorDonoghue, Een_NZ
dc.contributor.authorDreier, Jen_NZ
dc.contributor.authorDulière, GLen_NZ
dc.contributor.authorErcole, Aen_NZ
dc.contributor.authorEsser, Pen_NZ
dc.contributor.authorEzer, Een_NZ
dc.contributor.authorFabricius, Men_NZ
dc.contributor.authorFeigin, VLen_NZ
dc.contributor.authorFoks, Ken_NZ
dc.contributor.authorFrisvold, Sen_NZ
dc.contributor.authorFurmanov, Aen_NZ
dc.contributor.authorGagliardo, Pen_NZ
dc.contributor.authorGalanaud, Den_NZ
dc.contributor.authorGantner, Den_NZ
dc.contributor.authorGao, Gen_NZ
dc.contributor.authorGeorge, Pen_NZ
dc.contributor.authorGhuysen, Aen_NZ
dc.contributor.authorGiga, Len_NZ
dc.contributor.authorGlocker, Ben_NZ
dc.contributor.authorGolubovic, Jen_NZ
dc.contributor.authorGomez, PAen_NZ
dc.contributor.authorGratz, Jen_NZ
dc.contributor.authorGravesteijn, Ben_NZ
dc.contributor.authorGrossi, Fen_NZ
dc.contributor.authorGruen, RLen_NZ
dc.contributor.authorGupta, Den_NZ
dc.contributor.authorHaagsma, JAen_NZ
dc.contributor.authorHaitsma, Ien_NZ
dc.contributor.authorHelbok, Ren_NZ
dc.date.accessioned2022-08-04T00:04:16Z
dc.date.available2022-08-04T00:04:16Z
dc.date.copyright2022en_NZ
dc.date.issued2022en_NZ
dc.description.abstractComplex metabolic disruption is a crucial aspect of the pathophysiology of traumatic brain injury (TBI). Associations between this and systemic metabolism and their potential prognostic value are poorly understood. Here, we aimed to describe the serum metabolome (including lipidome) associated with acute TBI within 24 h post-injury, and its relationship to severity of injury and patient outcome. We performed a comprehensive metabolomics study in a cohort of 716 patients with TBI and non-TBI reference patients (orthopedic, internal medicine, and other neurological patients) from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) cohort. We identified panels of metabolites specifically associated with TBI severity and patient outcomes. Choline phospholipids (lysophosphatidylcholines, ether phosphatidylcholines and sphingomyelins) were inversely associated with TBI severity and were among the strongest predictors of TBI patient outcomes, which was further confirmed in a separate validation dataset of 558 patients. The observed metabolic patterns may reflect different pathophysiological mechanisms, including protective changes of systemic lipid metabolism aiming to maintain lipid homeostasis in the brain.en_NZ
dc.identifier.citationNature Communications 13, 2545 (2022). https://doi.org/10.1038/s41467-022-30227-5
dc.identifier.doi10.1038/s41467-022-30227-5en_NZ
dc.identifier.issn2041-1723en_NZ
dc.identifier.issn2041-1723en_NZ
dc.identifier.urihttps://hdl.handle.net/10292/15339
dc.publisherNature
dc.relation.urihttps://www.nature.com/articles/s41467-022-30227-5
dc.rights© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/.
dc.rights.accessrightsOpenAccessen_NZ
dc.subjectBiomarkers; Brain injuries; Diseases of the nervous system
dc.titleSerum Metabolome Associated With Severity of Acute Traumatic Brain Injuryen_NZ
dc.typeJournal Article
pubs.elements-id457925
pubs.organisational-data/AUT
pubs.organisational-data/AUT/Faculty of Health & Environmental Science
pubs.organisational-data/AUT/Faculty of Health & Environmental Science/National Institute Stroke & Applied Neurosciences
pubs.organisational-data/AUT/Faculty of Health & Environmental Science/School of Clinical Sciences
pubs.organisational-data/AUT/PBRF
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences/HY Public Health & Psychosocial Studies 2018 PBRF
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