SOX1 Autoantibody-associated Optic Neuritis: Coincidence or Correlation?
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Vegda, Monalisa
Dahiya, Ekta S
Dixit, Abhishek
Tomar, Nishant
Mehndiratta, Man M
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Ovid Technologies (Wolters Kluwer Health)
Abstract
Anti-Sry-like high mobility group box (SOX) 1 antibodies are the antibodies associated with paraneoplastic neurological disorders with the background of small-cell lung carcinoma. The most common of these paraneoplastic disorders are Lambert–Eaton myasthenic syndrome, cerebellar degeneration, and limbic encephalitis. Here, we report a novel case of an elderly diabetic lady with optic neuritis who had an elevated erythrocyte sedimentation rate and SOX1 antibody positivity by line blot essay along with cerebellar hypometabolism in fluorodeoxyglucose positron emission tomography imaging. We also discuss the management and treatment response of the patient.
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32 Biomedical and Clinical Sciences, 3202 Clinical Sciences, Rare Diseases, Biotechnology, Neurosciences, Autoimmune Disease, Brain Disorders, Eye Disease and Disorders of Vision
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Indian Journal of Ophthalmology - Case Reports, ISSN: 2772-3070 (Print); 2772-3089 (Online), Ovid Technologies (Wolters Kluwer Health), 6(3), 754-756. doi: 10.4103/ijo.ijo_2069_25
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Except where otherwise noted, this item's license is described as Creative Commons Attribution-NonCommercial-NoDerivatives 4.0