Association of Plasma C-reactive Protein With Ischemic Stroke: A Mendelian Randomization Study

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aut.filerelease.date2020-11-12
aut.relation.journalEuropean Journal of Neurologyen_NZ
aut.researcherFeigin, Valery
dc.contributor.authorZhang, Xen_NZ
dc.contributor.authorWang, Aen_NZ
dc.contributor.authorZhang, Jen_NZ
dc.contributor.authorSingh, Men_NZ
dc.contributor.authorLiu, Den_NZ
dc.contributor.authorZuo, Yen_NZ
dc.contributor.authorWu, Len_NZ
dc.contributor.authorSong, Men_NZ
dc.contributor.authorWang, Wen_NZ
dc.contributor.authorFeigin, VLen_NZ
dc.contributor.authorWang, Yen_NZ
dc.contributor.authorZheng, Den_NZ
dc.date.accessioned2019-11-12T02:36:30Z
dc.date.available2019-11-12T02:36:30Z
dc.date.copyright2019en_NZ
dc.date.issued2019en_NZ
dc.description.abstractBACKGROUND AND PURPOSE: Elevated C-reactive protein (CRP) is associated with an increased risk of ischemic stroke (IS). However, the causality of this association is uncertain. We aim to investigate whether genetically raised plasma CRP concentration levels are associated with the IS based on the Mendelian randomization (MR) method. METHODS: Based on the National Center for Biotechnology Information SNP database, the Chinese online genetic database as well as previously published studies, four CRP-associated SNPs alleles (rs1130864, rs1205, rs876537 and rs3093059) with minor allele frequency (MAF) ≥ 0.15 were selected and the concentration levels of CRP were measured in 378 first-ever IS patients and 613 healthy controls. RESULTS: Three SNPs were chosen and used as instrumental variables. The adjusted odds ratios (ORs) (95% confidence interval (95% CI)) of IS per addition of the modelled allele were 1.07 (0.79-1.45) for rs876537, 0.99 (0.73-1.35) for rs1205 and 1.08 (0.71-1.65) for rs3093059. The OR (95% CI) of IS for the plasma CRP ≥ 2.0 mg/L was 2.19 (1.06-4.53) as compared with < 2.0 mg/L. The adjusted OR (95% CI) of IS per genetically predicted 10% higher CRP concentration, based on the three SNPs as the instruments, was 1.02 (0.94-1.11). Furthermore, the similar results were obtained with the adjusted ORs (95% CI) of 1.00 (0.88-1.13) and 1.04 (0.93-1.16), respectively, for large-artery atherosclerosis and small-artery occlusion per genetically predicted 10% higher CRP concentration. CONCLUSIONS: This MR study provides no clear support that elevated CRP concentration is causally associated with the risk of IS.en_NZ
dc.identifier.citationEuropean Journal of Neurology, doi:10.1111/ene.14113
dc.identifier.doi10.1111/ene.14113en_NZ
dc.identifier.issn1351-5101en_NZ
dc.identifier.issn1468-1331en_NZ
dc.identifier.urihttps://hdl.handle.net/10292/12991
dc.languageengen_NZ
dc.publisherJohn Wiley & Sons
dc.relation.urihttps://onlinelibrary.wiley.com/doi/abs/10.1111/ene.14113
dc.rightsThis is the pre-peer reviewed version of the following article: [view Source], which has been published in final form at [doi: 10.1111/ene.14113]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
dc.rights.accessrightsOpenAccessen_NZ
dc.subjectC-reactive proteinen_NZ
dc.subjectMendelian randomizationen_NZ
dc.subjectOdds ratioen_NZ
dc.subjectSNPen_NZ
dc.subjectischemic strokeen_NZ
dc.titleAssociation of Plasma C-reactive Protein With Ischemic Stroke: A Mendelian Randomization Studyen_NZ
dc.typeJournal Article
pubs.elements-id365587
pubs.organisational-data/AUT
pubs.organisational-data/AUT/Health & Environmental Science
pubs.organisational-data/AUT/Health & Environmental Science/Public Health & Psych Studies
pubs.organisational-data/AUT/PBRF
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences/HY Public Health & Psychosocial Studies 2018 PBRF
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