Molecular basis of chemosensitivity of platinum pre-treated ovarian cancer to chemotherapy
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Authors
Glaysher, S
Gabriel, FG
Johnson, P
Polak, M
Knight, LA
Parker, K
Poole, M
Narayanan, A
Cree, IA
NHS Collaborative Research Programme for Predictive Oncology
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Nature Publishing Group
Abstract
Ovarian cancer shows considerable heterogeneity in its sensitivity to chemotherapy both clinically and in vitro. This study tested the hypothesis that the molecular basis of this difference lies within the known resistance mechanisms inherent to these patients' tumours.
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Keywords
Antineoplastic combined chemotherapy protocols, Busulfan, Cisplatin, Deoxycytidine, Drug resistance, Neoplasm, Drug screening assays, Antitumor, Female, Humans, Ovarian neoplasms, Topotecan
Source
Br J Cancer, vol.103(5), pp.656 - 662
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From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License.