Pilot study into the causes of airway drying during continuous positive air pressure breathing

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aut.relation.pages4,687 (7 Vols)
aut.researcherWhite, David Edward
dc.contributor.authorWhite, DE
dc.contributor.authorNates, RJ
dc.contributor.authorBartley, J
dc.date.accessioned2015-05-06T01:27:30Z
dc.date.available2015-05-06T01:27:30Z
dc.date.copyright2014-07-09
dc.date.issued2014-07-09
dc.description.abstractThe airway surface liquid (ASL) lining the upper respiratory tract has an essential role in heat and moisture exchange, as well as having an important role in airway defense. Continuous positive air pressure (CPAP) users frequently report troublesome symptoms of airway dryness and nasal congestion. Clinical investigations have demonstrated that supplementary humidification reduces these symptoms but the reason for their occurrence remains unexplained. Previously, symptoms of nasal drying have been attributed to unidirectional airflow created by mouth leaks; however these still occur when leaks are absent. Tidal breathing stresses have previously been shown to regulate epithelial cell ionic fluid secretion and reabsorption into the ASL [1]. The purpose of this study was to determine whether augmented air pressures change overall mucosal ASL water supply and, if so, the extent of this effect. It is hypothesized that the low-level positive airway pressures used in CPAP therapy could reduce the ability of respiratory mucosa to humidify inhaled air as a result of reduced ASL supply from the airway mucosa.
dc.identifier.citation7th World Congress in Biomechanics (WCB 2014) held at Boston, USA, Hynes Convention Centre, 2014-07-06to 2014-07-11, pp.? - ? (4,687 (7 Vols))
dc.identifier.isbn978-1-63-439381-2
dc.identifier.urihttps://hdl.handle.net/10292/8638
dc.publisherCurran Associates, Inc. (Jan 2015)
dc.relation.urihttp://www.wc-biomechanics.org/congresses/2014/
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in (see Citation). The original publication is available at (see Publisher's Version).
dc.rights.accessrightsOpenAccess
dc.titlePilot study into the causes of airway drying during continuous positive air pressure breathing
dc.typeConference Contribution
pubs.elements-id182833
pubs.organisational-data/AUT
pubs.organisational-data/AUT/Design & Creative Technologies
pubs.organisational-data/AUT/Design & Creative Technologies/School of Engineering
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