Oral Mucositis in Cancer and Potential Use of Omega-3 Free Fatty Acids in Its Management: A Review

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aut.relation.endpage1531
aut.relation.issue11en_NZ
aut.relation.journalBiomedicinesen_NZ
aut.relation.startpage1531
aut.relation.volume9en_NZ
aut.researcherLu, Jun
dc.contributor.authorLessa, RCen_NZ
dc.contributor.authorAlves, FDAen_NZ
dc.contributor.authorFortunati, Een_NZ
dc.contributor.authorLu, Jen_NZ
dc.date.accessioned2022-03-21T03:24:33Z
dc.date.available2022-03-21T03:24:33Z
dc.date.copyright2021en_NZ
dc.date.issued2021en_NZ
dc.description.abstractOral mucositis (OM) is a painful condition caused by chemotherapeutic or radiotherapeutic cancer treatments, occurring in patients with different tumour characteristics and locations. OM greatly impacts a patient’s quality of life and cancer recovery. Current OM management strategies are not providing sufficient prevention and treatment; new approaches to injury management are needed. Studies on the benefit of omega-3 free fatty acids (FFA) in human health have increased significantly in recent years. FFA properties have been studied extensively, including their potential therapeutic use in inflammatory conditions. However, omega-3 FFA’s use as a supplementary treatment for OM has not been clinically tested. Preliminary evidence suggests that utilising FFA to manage OM could be a useful strategy for lesion management, assisting with healthy oral mucosa recovery. This review will describe the incidence, risk factors, biology of OM and the current treatment strategies, leading to a discussion of the utility of omega-3 FFA as a novel therapeutic agent for OM.en_NZ
dc.identifier.citationBiomedicines, 9(11), 1531. https://doi.org/10.3390/biomedicines9111531
dc.identifier.doi10.3390/biomedicines9111531en_NZ
dc.identifier.issn2227-9059en_NZ
dc.identifier.urihttps://hdl.handle.net/10292/15009
dc.languageenen_NZ
dc.publisherMDPI AGen_NZ
dc.relation.urihttps://www.mdpi.com/2227-9059/9/11/1531
dc.rights© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
dc.rights.accessrightsOpenAccessen_NZ
dc.subjectOral mucositis; Inflammation; Polyunsaturated fatty acids; Omega-3 fatty acids; Omega-6 fatty acids; Cancer; Prostaglandins; Leukotrienes; Interleukins; Cytokines
dc.titleOral Mucositis in Cancer and Potential Use of Omega-3 Free Fatty Acids in Its Management: A Reviewen_NZ
dc.typeJournal Article
pubs.elements-id442697
pubs.organisational-data/AUT
pubs.organisational-data/AUT/Faculty of Health & Environmental Science
pubs.organisational-data/AUT/Faculty of Health & Environmental Science/School of Public Health & Interdisciplinary Studies
pubs.organisational-data/AUT/Faculty of Health & Environmental Science/School of Public Health & Interdisciplinary Studies/Biosciences Department
pubs.organisational-data/AUT/PBRF
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences/HI Interprofessional 2018 PBRF
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