dc.contributor.author	Wheldon, MC	en_NZ
dc.contributor.author	Vandal, AC	en_NZ
dc.contributor.author	Bourien, AC	en_NZ
dc.contributor.author	Jayaram, L	en_NZ
dc.contributor.author	Karalus, N	en_NZ
dc.contributor.author	Tong, C	en_NZ
dc.contributor.author	Hockey, H	en_NZ
dc.contributor.author	Wong, C	en_NZ
dc.date.accessioned	2015-09-15T03:15:03Z
dc.date.available	2015-09-15T03:15:03Z
dc.date.copyright	2015-08-12	en_NZ
dc.date.issued	2015-08-12	en_NZ
dc.description.abstract	The EMBRACE multi-center RCT evaluated the effect of azithromycin on frequency of event-based exacerbations (EBEs), lung function and health-related quality of life in adult patients with non-cystic fibrosis bronchiectasis. The treatment was effective in lowering the rate of EBEs relative to placebo (Wong et al., Lancet 2012 380(9842):660--7). An EBE, a binary outcome, is a sustained worsening of condition requiring treatment with antibiotics. Respiratory condition is defined, partly, in terms of daily sputum volume, sputum purulence, and dyspnoea, recorded daily in diaries kept by participants. Quality of life, as measured by the St. George's respiratory questionnaire, was also recorded in the diaries. Here, we use the daily diary entries to build a statistical model to estimate the probability that an EBE is imminent. A definition of symptom-based exacerbation (SBE) is developed by comparing the ROC curves of logistic regression models with EBE as the response and respiratory condition over different time windows as the predictors. Predictive accuracy is estimated using cross-validation. The new SBE definition is validated against self-reported quality of life.	en_NZ
dc.identifier.citation	Joint Statistical Meetings held at Washington State Convention Center, Seattle, WA, United States of America, 2015-08-09to 2015-08-13	en_NZ
dc.identifier.uri	https://hdl.handle.net/10292/9062
dc.publisher	American Statistical Association (ASA)
dc.relation.uri	https://www.amstat.org/meetings/jsm/2015/onlineprogram/AbstractDetails.cfm?abstractid=315070
dc.rights	Authors retain copyright on individual papers published in the JSM Proceedings. Eligible presenters are not prohibited from publishing in the JSM Proceedings as well as other publications; authors are advised to consult journal exclusivity agreements for restrictions.
dc.rights.accessrights	OpenAccess	en_NZ
dc.subject	Logistic regression ; Predictive model ; Bronchiectasis ; Exacerbation ; Respiratory condition
dc.title	Automatic adjudication of symptom-based exacerbations in bronchiectasis patients treated with Azithromycin	en_NZ
dc.type	Conference Contribution
pubs.elements-id	190287
pubs.organisational-data	/AUT
pubs.organisational-data	/AUT/Health & Environmental Science

Automatic adjudication of symptom-based exacerbations in bronchiectasis patients treated with Azithromycin

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