Sleep Architecture, Insulin Resistance and the Nasal Cycle: Implications for Positive Airway Pressure Therapy
aut.relation.endpage | 6 | |
aut.relation.issue | 1 | en_NZ |
aut.relation.journal | Journal of Insulin Resistance | en_NZ |
aut.relation.pages | 6 | |
aut.relation.startpage | 1 | |
aut.relation.volume | 3 | en_NZ |
aut.researcher | White, David | |
dc.contributor.author | Crofts, CAP | en_NZ |
dc.contributor.author | Neill, A | en_NZ |
dc.contributor.author | Campbell, A | en_NZ |
dc.contributor.author | Bartley, J | en_NZ |
dc.contributor.author | White, DE | en_NZ |
dc.date.accessioned | 2019-07-15T00:22:59Z | |
dc.date.available | 2019-07-15T00:22:59Z | |
dc.date.copyright | 2018-03-28 | en_NZ |
dc.date.issued | 2018-03-28 | en_NZ |
dc.description.abstract | Background: The global pandemic of metabolic disease is worsening. The metabolic theory of obesity proposes that hormonal changes, especially hyperinsulinaemia, precede metabolic disease development. Although quality sleep is recognised as a key factor for good health, less is known about disrupted sleep as a risk factor for hyperinsulinaemia. Aim: To explore the relationship between sleep, especially sleep architecture and the nasal cycle, on insulin secretion in obstructive sleep apnoea (OSA) with comorbid metabolic disease. This review includes a discussion of the potential role of Rest-Activity-Cycler positive airway pressure (RACer-PAP), a novel non-pharmacological OSA treatment strategy. Methods: A narrative review of all the relevant papers known to the authors was conducted. This review also included results from a polysomnographic sleep clinic pilot study (n = 3) comparing sleep efficiency of RACer-PAP to nasal continuous positive airways pressure (n-CPAP) in OSA patients. Results: Metabolic disease is strongly associated with disturbed sleep. Sleep architecture influences cerebral hormonal secretion, lateral shifts in the autonomic nervous system and nasal airflow dominance. Disturbed sleep shortens short-wave sleep periods, decreasing insulin sensitivity and glucose tolerance. Improvements to metabolic function during n-CPAP treatment are inconsistent. If RACer-PAP demonstrates superior effects on sleep architecture and autonomic function, it may offer advantages in OSA patients with comorbid metabolic disease. Conclusion: Improving sleep architecture by maintaining the nasal cycle proposes a novel non-pharmacological treatment paradigm for treating OSA with comorbid metabolic disease. Research is required to demonstrate if RACer-PAP therapy influences whole night sleep architecture, sympathovagal balance and markers of metabolic disease. | en_NZ |
dc.identifier.citation | Journal of Insulin Resistance, 3(1), 1-6. | |
dc.identifier.doi | 10.4102/jir.v3i1.34 | en_NZ |
dc.identifier.issn | 2412-2785 | en_NZ |
dc.identifier.uri | https://hdl.handle.net/10292/12662 | |
dc.publisher | AOSIS | en_NZ |
dc.relation.uri | https://insulinresistance.org/index.php/jir/article/view/34 | en_NZ |
dc.rights | © 2018. The Authors. Licensee: AOSIS. This work is licensed under the Creative Commons Attribution License. | |
dc.rights.accessrights | OpenAccess | en_NZ |
dc.subject | Sleep apnoea; Metabolic disease; Sympathovagal balance; Sleep architecture; Hyperinsulinaemia | |
dc.title | Sleep Architecture, Insulin Resistance and the Nasal Cycle: Implications for Positive Airway Pressure Therapy | en_NZ |
dc.type | Journal Article | |
pubs.elements-id | 334187 | |
pubs.organisational-data | /AUT | |
pubs.organisational-data | /AUT/Design & Creative Technologies | |
pubs.organisational-data | /AUT/Design & Creative Technologies/Engineering, Computer & Mathematical Sciences | |
pubs.organisational-data | /AUT/PBRF | |
pubs.organisational-data | /AUT/PBRF/PBRF Design and Creative Technologies | |
pubs.organisational-data | /AUT/PBRF/PBRF Design and Creative Technologies/PBRF ECMS |
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