Cerebellar Transcranial Direct Current Stimulation for Learning a Novel Split-belt Treadmill Task: A Randomised Controlled Trial

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aut.relation.articlenumber11853en_NZ
aut.relation.issue1en_NZ
aut.relation.journalScientific Reportsen_NZ
aut.relation.volume10en_NZ
aut.researcherDrabsch, Julie
dc.contributor.authorKumari, Nen_NZ
dc.contributor.authorTaylor, Den_NZ
dc.contributor.authorRashid, Uen_NZ
dc.contributor.authorVandal, ACen_NZ
dc.contributor.authorSmith, PFen_NZ
dc.contributor.authorSignal, Nen_NZ
dc.date.accessioned2020-08-05T04:24:10Z
dc.date.available2020-08-05T04:24:10Z
dc.date.copyright2020en_NZ
dc.date.issued2020en_NZ
dc.description.abstractThis study aimed to examine the effect of repeated anodal cerebellar transcranial direct current stimulation (ctDCS) on learning a split-belt treadmill task. Thirty healthy individuals randomly received three consecutive sessions of active or sham anodal ctDCS during split-belt treadmill training. Motor performance and strides to steady-state performance were evaluated before (baseline), during (adaptation), and after (de-adaptation) the intervention. The outcomes were measured one week later to assess absolute learning and during the intervention to evaluate cumulative, consecutive, and session-specific effects. Data were analysed using linear mixed-effects regression models. During adaptation, there was no significant difference in absolute learning between the groups (p > 0.05). During de-adaptation, a significant difference in absolute learning between the groups (p = 0.03) indicated slower de-adaptation with anodal ctDCS. Pre-planned secondary analysis revealed that anodal ctDCS significantly reduced the cumulative (p = 0.01) and consecutive-session effect (p = 0.01) on immediate adaptation. There were significant cumulative (p = 0.02) and session-specific effects (p = 0.003) on immediate de-adaptation. Repeated anodal ctDCS does not enhance motor learning measured during adaptation to a split-belt treadmill task. However, it influences the maintenance of learnt walking patterns, suggesting that it may be beneficial in maintaining therapeutic effects.en_NZ
dc.identifier.citationScientific Reports, 10 (1), 1-14.
dc.identifier.doi10.1038/s41598-020-68825-2en_NZ
dc.identifier.issn2045-2322en_NZ
dc.identifier.issn2045-2322en_NZ
dc.identifier.urihttps://hdl.handle.net/10292/13582
dc.languageengen_NZ
dc.publisherNature Publishing Groupen_NZ
dc.relation.urihttps://www.nature.com/articles/s41598-020-68825-2
dc.rights© The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
dc.rights.accessrightsOpenAccessen_NZ
dc.subjectRandomized controlled trials; Therapeutics
dc.titleCerebellar Transcranial Direct Current Stimulation for Learning a Novel Split-belt Treadmill Task: A Randomised Controlled Trialen_NZ
dc.typeJournal Article
pubs.elements-id384584
pubs.organisational-data/AUT
pubs.organisational-data/AUT/Health & Environmental Science
pubs.organisational-data/AUT/Health & Environmental Science/Clinical Sciences
pubs.organisational-data/AUT/PBRF
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences/HH Clinical Sciences 2018 PBRF
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