The Effect of Chronotropic Incompetence on Physiologic Responses During Progressive Exercise in People with Parkinson’s Disease

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aut.relation.endpage2807
aut.relation.issue9
aut.relation.journalEuropean Journal of Applied Physiology
aut.relation.startpage2799
aut.relation.volume124
dc.contributor.authorBenevides Panassollo, Tone Ricardo
dc.contributor.authorLord, Sue
dc.contributor.authorRashid, Usman
dc.contributor.authorTaylor, Denise
dc.contributor.authorMawston, Grant
dc.date.accessioned2024-11-12T01:35:59Z
dc.date.available2024-11-12T01:35:59Z
dc.date.issued2024-04-29
dc.description.abstractPURPOSE: Heart rate (HR) response is likely to vary in people with Parkinson's disease (PD), particularly for those with chronotropic incompetence (CI). This study explores the impact of CI on HR and metabolic responses during cardiopulmonary exercise test (CPET) in people with PD, and its implications for exercise intensity prescription. METHODS: Twenty-eight participants with mild PD and seventeen healthy controls underwent CPET to identify the presence or absence of CI. HR and metabolic responses were measured at submaximal (first (VT1) and second (VT2) ventilatory thresholds), and at peak exercise. Main outcome measures were HR, oxygen consumption (VO2), and changes in HR responses (HR/WR slope) to an increase in exercise demand. RESULTS: CI was present in 13 (46%) PD participants (PDCI), who during CPET, exhibited blunted HR responses compared to controls and PD non-CI beyond 60% of maximal workload (p ≤ 0.05). PDCI presented a significantly lower HR at VT2, and peak exercise compared to PD non-CI and controls (p ≤ 0.001). VO2 was significantly lower in PDCI than PD non-CI and controls at VT2 (p = 0.003 and p = 0.036, respectively) and at peak exercise (p = 0.001 and p = 0.023, respectively). CONCLUSION: Although poorly understood, the presence of CI in PD and its effect on HR and metabolic responses during incremental exercise is significant and important to consider when programming aerobic exercises.
dc.identifier.citationEuropean Journal of Applied Physiology, ISSN: 1439-6319 (Print); 1439-6327 (Online), Springer, 124(9), 2799-2807. doi: 10.1007/s00421-024-05492-5
dc.identifier.doi10.1007/s00421-024-05492-5
dc.identifier.issn1439-6319
dc.identifier.issn1439-6327
dc.identifier.urihttp://hdl.handle.net/10292/18285
dc.languageeng
dc.publisherSpringer
dc.relation.urihttp://dx.doi.org/10.1007/s00421-024-05492-5
dc.rightsOpen Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
dc.rights.accessrightsOpenAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCardiopulmonary exercise test
dc.subjectExercise prescription
dc.subjectHeart rate
dc.subjectOxygen consumption
dc.subjectCardiopulmonary exercise test
dc.subjectExercise prescription
dc.subjectHeart rate
dc.subjectOxygen consumption
dc.subject42 Health Sciences
dc.subject4207 Sports Science and Exercise
dc.subjectPhysical Activity
dc.subjectNeurosciences
dc.subjectClinical Trials and Supportive Activities
dc.subjectParkinson's Disease
dc.subjectBrain Disorders
dc.subjectClinical Research
dc.subjectAging
dc.subjectNeurodegenerative
dc.subject2.1 Biological and endogenous factors
dc.subjectNeurological
dc.subject1106 Human Movement and Sports Sciences
dc.subjectSport Sciences
dc.subject3202 Clinical sciences
dc.subject3208 Medical physiology
dc.subject4207 Sports science and exercise
dc.subject.meshHumans
dc.subject.meshParkinson Disease
dc.subject.meshMale
dc.subject.meshFemale
dc.subject.meshHeart Rate
dc.subject.meshOxygen Consumption
dc.subject.meshMiddle Aged
dc.subject.meshAged
dc.subject.meshExercise
dc.subject.meshExercise Test
dc.subject.meshHumans
dc.subject.meshParkinson Disease
dc.subject.meshExercise Test
dc.subject.meshExercise
dc.subject.meshOxygen Consumption
dc.subject.meshHeart Rate
dc.subject.meshAged
dc.subject.meshMiddle Aged
dc.subject.meshFemale
dc.subject.meshMale
dc.subject.meshHumans
dc.subject.meshParkinson Disease
dc.subject.meshMale
dc.subject.meshFemale
dc.subject.meshHeart Rate
dc.subject.meshOxygen Consumption
dc.subject.meshMiddle Aged
dc.subject.meshAged
dc.subject.meshExercise
dc.subject.meshExercise Test
dc.titleThe Effect of Chronotropic Incompetence on Physiologic Responses During Progressive Exercise in People with Parkinson’s Disease
dc.typeJournal Article
pubs.elements-id546669
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