Global, Regional, and National Burden of Neurological Disorders During 1990-2015: A Systematic Analysis for the Global Burden of Disease Study 2015

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aut.relation.endpage897
aut.relation.issue11en_NZ
aut.relation.journalLancet Neurologyen_NZ
aut.relation.startpage877
aut.relation.volume16en_NZ
aut.researcherFeigin, Valery
dc.contributor.authorFeigin, VLen_NZ
dc.contributor.authorAbajobir, AAen_NZ
dc.contributor.authorAbate, KHen_NZ
dc.contributor.authorAbd-Allah, Fen_NZ
dc.contributor.authorAbdulle, AMen_NZ
dc.contributor.authorAbera, SFen_NZ
dc.contributor.authorAbyu, GYen_NZ
dc.contributor.authorAhmed, MBen_NZ
dc.contributor.authorAichour, ANen_NZ
dc.contributor.authorAichour, Ien_NZ
dc.contributor.authorAichour, MTEen_NZ
dc.contributor.authorAkinyemi, ROen_NZ
dc.contributor.authorAlabed, Sen_NZ
dc.contributor.authorAl-Raddadi, Ren_NZ
dc.contributor.authorAlvis-Guzman, Nen_NZ
dc.contributor.authorAmare, ATen_NZ
dc.contributor.authorAnsari, Hen_NZ
dc.contributor.authorAnwari, Pen_NZ
dc.contributor.authorArnlov, Jen_NZ
dc.contributor.authorAsayesh, Hen_NZ
dc.contributor.authorAsgedom, SWen_NZ
dc.contributor.authorAtey, TMen_NZ
dc.contributor.authorAvila-Burgos, Len_NZ
dc.contributor.authorAvokpaho, EFGAen_NZ
dc.contributor.authorAzarpazhooh, MRen_NZ
dc.contributor.authorBarac, Aen_NZ
dc.contributor.authorBarboza, Men_NZ
dc.contributor.authorBarker-Collo, SLen_NZ
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dc.contributor.authorBedi, Nen_NZ
dc.contributor.authorBeghi, Een_NZ
dc.contributor.authorBennett, DAen_NZ
dc.contributor.authorBensenor, IMen_NZ
dc.contributor.authorBerhane, Aen_NZ
dc.contributor.authorBetsu, BDen_NZ
dc.contributor.authorBhaumik, Sen_NZ
dc.contributor.authorBirlik, SMen_NZ
dc.contributor.authorBiryukov, Sen_NZ
dc.contributor.authorBoneya, DJen_NZ
dc.contributor.authorBulto, LNen_NZ
dc.contributor.authorCarabin, Hen_NZ
dc.contributor.authorCasey, Den_NZ
dc.contributor.authorCastaneda-Orjuela, CAen_NZ
dc.contributor.authorCatala-Lopez, Fen_NZ
dc.contributor.authorChen, Hen_NZ
dc.contributor.authorChitheer, AAen_NZ
dc.contributor.authorChowdhury, Ren_NZ
dc.contributor.authorChristensen, Hen_NZ
dc.contributor.authorDandona, Len_NZ
dc.contributor.authorDandona, Ren_NZ
dc.contributor.authordeVeber, GAen_NZ
dc.contributor.authorDharmaratne, SDen_NZ
dc.contributor.authorDo, HPen_NZ
dc.contributor.authorDokova, Ken_NZ
dc.contributor.authorDorsey, ERen_NZ
dc.contributor.authorEllenbogen, RGen_NZ
dc.contributor.authorEskandarieh, Sen_NZ
dc.contributor.authorFarvid, MSen_NZ
dc.contributor.authorFereshtehnejad, S-Men_NZ
dc.contributor.authorFischer, Fen_NZ
dc.contributor.authorForeman, KJen_NZ
dc.contributor.authorGeleijnse, JMen_NZ
dc.contributor.authorGillum, RFen_NZ
dc.contributor.authorGiussani, Gen_NZ
dc.contributor.authorGoldberg, EMen_NZ
dc.contributor.authorGona, PNen_NZ
dc.contributor.authorGoulart, ACen_NZ
dc.contributor.authorGugnani, HCen_NZ
dc.contributor.authorGupta, Ren_NZ
dc.contributor.authorGupta, Ren_NZ
dc.contributor.authorHachinski, Ven_NZ
dc.contributor.authorHamadeh, RRen_NZ
dc.contributor.authorHambisa, Men_NZ
dc.contributor.authorHankey, GJen_NZ
dc.contributor.authorHareri, HAen_NZ
dc.contributor.authorHavmoeller, Ren_NZ
dc.contributor.authorHay, SIen_NZ
dc.contributor.authorHeydarpour, Pen_NZ
dc.contributor.authorHotez, PJen_NZ
dc.contributor.authorJakovljevic, MMBen_NZ
dc.contributor.authorJavanbakht, Men_NZ
dc.contributor.authorJeemon, Pen_NZ
dc.contributor.authorJonas, JBen_NZ
dc.contributor.authorKalkonde, Yen_NZ
dc.contributor.authorKandel, Aen_NZ
dc.contributor.authorKarch, Aen_NZ
dc.contributor.authorKasaeian, Aen_NZ
dc.contributor.authorKastor, Aen_NZ
dc.contributor.authorKeiyoro, PNen_NZ
dc.contributor.authorKhader, YSen_NZ
dc.contributor.authorKhalil, IAen_NZ
dc.contributor.authorKhan, EAen_NZ
dc.contributor.authorKhang, Y-Hen_NZ
dc.contributor.authorKhoja, ATen_NZ
dc.contributor.authorKhubchandani, Jen_NZ
dc.contributor.authorKulkarni, Cen_NZ
dc.contributor.authorKim, Den_NZ
dc.contributor.authorKim, YJen_NZ
dc.contributor.authorKivimaki, Men_NZ
dc.contributor.authorKokubo, Yen_NZ
dc.contributor.authorKosen, Sen_NZ
dc.contributor.authorKravchenko, Men_NZ
dc.contributor.authorKrishnamurthi, RVen_NZ
dc.contributor.authorDefo, BKen_NZ
dc.contributor.authorKumar, GAen_NZ
dc.contributor.authorKumar, Ren_NZ
dc.contributor.authorKyu, HHen_NZ
dc.contributor.authorLarsson, Aen_NZ
dc.contributor.authorLavados, PMen_NZ
dc.contributor.authorLi, Yen_NZ
dc.contributor.authorLiang, Xen_NZ
dc.contributor.authorLiben, MLen_NZ
dc.contributor.authorLo, WDen_NZ
dc.contributor.authorLogroscino, Gen_NZ
dc.contributor.authorLotufo, PAen_NZ
dc.contributor.authorLoy, CTen_NZ
dc.contributor.authorMackay, MTen_NZ
dc.contributor.authorAbd El Razek, HMen_NZ
dc.contributor.authorAbd El Razek, MMen_NZ
dc.contributor.authorMajeed, Aen_NZ
dc.contributor.authorMalekzadeh, Ren_NZ
dc.contributor.authorManhertz, Ten_NZ
dc.contributor.authorMantovani, LGen_NZ
dc.contributor.authorMassano, Jen_NZ
dc.contributor.authorMazidi, Men_NZ
dc.contributor.authorMcAlinden, Cen_NZ
dc.contributor.authorMehata, Sen_NZ
dc.contributor.authorMehndiratta, MMen_NZ
dc.contributor.authorMemish, ZAen_NZ
dc.contributor.authorMendoza, Wen_NZ
dc.contributor.authorMengistie, MAen_NZ
dc.contributor.authorMensah, GAen_NZ
dc.contributor.authorMeretoja, Aen_NZ
dc.contributor.authorMezgebe, HBen_NZ
dc.contributor.authorMiller, TRen_NZ
dc.contributor.authorMishra, SRen_NZ
dc.contributor.authorIbrahim, NMen_NZ
dc.contributor.authorMohammadi, Aen_NZ
dc.contributor.authorMohammed, KEen_NZ
dc.contributor.authorMohammed, Sen_NZ
dc.contributor.authorMokdad, AHen_NZ
dc.contributor.authorMoradi-Lakeh, Men_NZ
dc.contributor.authorVelasquez, IMen_NZ
dc.contributor.authorMusa, KIen_NZ
dc.contributor.authorNaghavi, Men_NZ
dc.contributor.authorNgunjiri, JWen_NZ
dc.contributor.authorNguyen, CTen_NZ
dc.contributor.authorNguyen, Gen_NZ
dc.contributor.authorNguyen, QLen_NZ
dc.contributor.authorNguyen, THen_NZ
dc.contributor.authorNichols, Een_NZ
dc.contributor.authorNingrum, DNen_NZ
dc.contributor.authorNong, VMen_NZ
dc.contributor.authorNorrving, Ben_NZ
dc.contributor.authorNoubiap, JJNen_NZ
dc.contributor.authorOgbo, FAen_NZ
dc.contributor.authorOwolabi, MOen_NZ
dc.contributor.authorPandian, JDen_NZ
dc.contributor.authorParmar, PGen_NZ
dc.contributor.authorPereira, DMen_NZ
dc.contributor.authorPetzold, Men_NZ
dc.contributor.authorPhillips, MRen_NZ
dc.contributor.authorPiradov, MAen_NZ
dc.contributor.authorPoulton, RGen_NZ
dc.contributor.authorPourmalek, Fen_NZ
dc.contributor.authorQorbani, Men_NZ
dc.contributor.authorRafay, Aen_NZ
dc.contributor.authorRahman, Men_NZ
dc.contributor.authorRahman, MHen_NZ
dc.contributor.authorRai, RKen_NZ
dc.contributor.authorRajsic, Sen_NZ
dc.contributor.authorRanta, Aen_NZ
dc.contributor.authorRawaf, Sen_NZ
dc.contributor.authorRenzaho, AMNen_NZ
dc.contributor.authorRezai, MSen_NZ
dc.contributor.authorRoth, GAen_NZ
dc.contributor.authorRoshandel, Gen_NZ
dc.contributor.authorRubagotti, Een_NZ
dc.contributor.authorSachdev, Pen_NZ
dc.contributor.authorSafiri, Sen_NZ
dc.contributor.authorSahathevan, Ren_NZ
dc.contributor.authorSahraian, MAen_NZ
dc.contributor.authorSamy, AMen_NZ
dc.contributor.authorSantalucia, Pen_NZ
dc.contributor.authorSantos, ISen_NZ
dc.contributor.authorSartorius, Ben_NZ
dc.contributor.authorSatpathy, Men_NZ
dc.contributor.authorSawhney, Men_NZ
dc.contributor.authorSaylan, MIen_NZ
dc.contributor.authorSepanlou, SGen_NZ
dc.contributor.authorShaikh, MAen_NZ
dc.contributor.authorShakir, Ren_NZ
dc.contributor.authorShamsizadeh, Men_NZ
dc.contributor.authorSheth, KNen_NZ
dc.contributor.authorShigematsu, Men_NZ
dc.contributor.authorShoman, Hen_NZ
dc.contributor.authorSilva, DAen_NZ
dc.contributor.authorSmith, Men_NZ
dc.contributor.authorSobngwi, Een_NZ
dc.contributor.authorSposato, LAen_NZ
dc.contributor.authorStanaway, JDen_NZ
dc.contributor.authorStein, DJen_NZ
dc.contributor.authorSteiner, TJen_NZ
dc.contributor.authorStovner, LJen_NZ
dc.contributor.authorAbdulkader, RSen_NZ
dc.contributor.authorSzoeke, CEIen_NZ
dc.contributor.authorTabares-Seisdedos, Ren_NZ
dc.contributor.authorTanne, Den_NZ
dc.contributor.authorTheadom, AMen_NZ
dc.contributor.authorThrift, AGen_NZ
dc.contributor.authorTirschwell, DLen_NZ
dc.contributor.authorTopor-Madry, Ren_NZ
dc.contributor.authorTran, BXen_NZ
dc.contributor.authorTruelsen, Ten_NZ
dc.contributor.authorTuem, KBen_NZ
dc.contributor.authorUkwaja, KNen_NZ
dc.contributor.authorUthman, OAen_NZ
dc.contributor.authorVarakin, YYen_NZ
dc.contributor.authorVasankari, Ten_NZ
dc.contributor.authorVenketasubramanian, Nen_NZ
dc.contributor.authorVlassov, VVen_NZ
dc.contributor.authorWadilo, Fen_NZ
dc.contributor.authorWakayo, Ten_NZ
dc.contributor.authorWallin, MTen_NZ
dc.contributor.authorWeiderpass, Een_NZ
dc.contributor.authorWesterman, Ren_NZ
dc.contributor.authorWijeratne, Ten_NZ
dc.contributor.authorWiysonge, CSen_NZ
dc.contributor.authorWoldu, MAen_NZ
dc.contributor.authorWolfe, CDAen_NZ
dc.contributor.authorXavier, Den_NZ
dc.contributor.authorXu, Gen_NZ
dc.contributor.authorYano, Yen_NZ
dc.contributor.authorYimam, HHen_NZ
dc.contributor.authorYonemoto, Nen_NZ
dc.contributor.authorYu, Cen_NZ
dc.contributor.authorZaidi, Zen_NZ
dc.contributor.authorZaki, MESen_NZ
dc.contributor.authorZunt, JRen_NZ
dc.contributor.authorMurray, CJLen_NZ
dc.contributor.authorVos, Ten_NZ
dc.contributor.authorDisorders, GBDNen_NZ
dc.date.accessioned2019-04-03T01:44:48Z
dc.date.available2019-04-03T01:44:48Z
dc.date.copyright2017en_NZ
dc.date.issued2017en_NZ
dc.description.abstractBackground Comparable data on the global and country-specific burden of neurological disorders and their trends are crucial for health-care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study provides such information but does not routinely aggregate results that are of interest to clinicians specialising in neurological conditions. In this systematic analysis, we quantified the global disease burden due to neurological disorders in 2015 and its relationship with country development level. Methods We estimated global and country-specific prevalence, mortality, disability-adjusted life-years (DALYs), years of life lost (YLLs), and years lived with disability (YLDs) for various neurological disorders that in the GBD classification have been previously spread across multiple disease groupings. The more inclusive grouping of neurological disorders included stroke, meningitis, encephalitis, tetanus, Alzheimer's disease and other dementias, Parkinson's disease, epilepsy, multiple sclerosis, motor neuron disease, migraine, tension-type headache, medication overuse headache, brain and nervous system cancers, and a residual category of other neurological disorders. We also analysed results based on the Socio-demographic Index (SDI), a compound measure of income per capita, education, and fertility, to identify patterns associated with development and how countries fare against expected outcomes relative to their level of development. Findings Neurological disorders ranked as the leading cause group of DALYs in 2015 (250·7 [95% uncertainty interval (UI) 229·1 to 274·7] million, comprising 10·2% of global DALYs) and the second-leading cause group of deaths (9·4 [9·1 to 9·7] million], comprising 16·8% of global deaths). The most prevalent neurological disorders were tension-type headache (1505·9 [UI 1337·3 to 1681·6 million cases]), migraine (958·8 [872·1 to 1055·6] million), medication overuse headache (58·5 [50·8 to 67·4 million]), and Alzheimer's disease and other dementias (46·0 [40·2 to 52·7 million]). Between 1990 and 2015, the number of deaths from neurological disorders increased by 36·7%, and the number of DALYs by 7·4%. These increases occurred despite decreases in age-standardised rates of death and DALYs of 26·1% and 29·7%, respectively; stroke and communicable neurological disorders were responsible for most of these decreases. Communicable neurological disorders were the largest cause of DALYs in countries with low SDI. Stroke rates were highest at middle levels of SDI and lowest at the highest SDI. Most of the changes in DALY rates of neurological disorders with development were driven by changes in YLLs. Interpretation Neurological disorders are an important cause of disability and death worldwide. Globally, the burden of neurological disorders has increased substantially over the past 25 years because of expanding population numbers and ageing, despite substantial decreases in mortality rates from stroke and communicable neurological disorders. The number of patients who will need care by clinicians with expertise in neurological conditions will continue to grow in coming decades. Policy makers and health-care providers should be aware of these trends to provide adequate services.
dc.identifier.citationThe Lancet Neurology, Volume 16, Issue 11, 2017, pp. 877-897.
dc.identifier.doi10.1016/S1474-4422(17)30299-5en_NZ
dc.identifier.issn1474-4422en_NZ
dc.identifier.issn1474-4465en_NZ
dc.identifier.urihttps://hdl.handle.net/10292/12412
dc.publisherElsevieren_NZ
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S1474442217302995?via%3Dihub
dc.rights© The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC-BY 4.0 license.
dc.rights.accessrightsOpenAccessen_NZ
dc.titleGlobal, Regional, and National Burden of Neurological Disorders During 1990-2015: A Systematic Analysis for the Global Burden of Disease Study 2015en_NZ
dc.typeJournal Article
pubs.elements-id315678
pubs.organisational-data/AUT
pubs.organisational-data/AUT/Health & Environmental Science
pubs.organisational-data/AUT/Health & Environmental Science/Public Health & Psych Studies
pubs.organisational-data/AUT/PBRF
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences/HY Public Health & Psychosocial Studies 2018 PBRF
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