The Oral Microbiome of Patients With Axial Spondyloarthritis Compared to Healthy Individuals

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aut.relation.issue6en_NZ
aut.relation.journalPeerJen_NZ
aut.relation.volume2016en_NZ
aut.researcherNolan, Anita
dc.contributor.authorBisanz, JEen_NZ
dc.contributor.authorSuppiah, Pen_NZ
dc.contributor.authorThomson, WMen_NZ
dc.contributor.authorMilne, Ten_NZ
dc.contributor.authorYeoh, Nen_NZ
dc.contributor.authorNolan, Aen_NZ
dc.contributor.authorEttinger, Gen_NZ
dc.contributor.authorReid, Gen_NZ
dc.contributor.authorGloor, GBen_NZ
dc.contributor.authorBurton, JPen_NZ
dc.contributor.authorCullinan, MPen_NZ
dc.contributor.authorStebbings, SMen_NZ
dc.date.accessioned2016-11-30T01:48:53Z
dc.date.available2016-11-30T01:48:53Z
dc.date.copyright2016en_NZ
dc.date.issued2016en_NZ
dc.description.abstractBackground. A loss of mucosal tolerance to the resident microbiome has been postulated in the aetiopathogenesis of spondyloarthritis, thus the purpose of these studies was to investigate microbial communities that colonise the oral cavity of patients with axial spondyloarthritis (AxSpA) and to compare these with microbial profiles of a matched healthy population. Methods. Thirty-nine participants, 17 patients with AxSpA and 22 age and gender- matched disease-free controls were recruited to the study. For patients with AxSpA, disease activity was assessed using the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). All participants underwent a detailed dental examination to assess oral health, including the presence of periodontal disease assessed using probing pocket depth (PPD). Plaque samples were obtained and their bacterial populations were profiled using Ion Torrent sequencing of the V6 region of the 16S rRNA gene. Results. Patients with AxSpA had active disease (BASDAI 4.1±2.1 [mean±SD]), and a significantly greater prevalence of periodontitis (PPD ≥ 4 mm at ≥ 4 sites) than controls. Bacterial communities did not differ between the two groups with multiple metrics of α and β diversity considered. Analysis of operational taxonomic units (OTUs) and higher levels of taxonomic assignment did not provide strong evidence of any single taxa associated with AxSpA in the subgingival plaque. Discussion. Although 16S rRNA gene sequencing did not identify specific bacterial profiles associated with AxSpA, there remains the potential for the microbiota to exert functional and metabolic influences in the oral cavity which could be involved in the pathogenesis of AxSpA.en_NZ
dc.identifier.citationPeerJ 4:e2095 https://doi.org/10.7717/peerj.2095
dc.identifier.doi10.7717/peerj.2095en_NZ
dc.identifier.issn2167-8359en_NZ
dc.identifier.urihttps://hdl.handle.net/10292/10238
dc.languageengen_NZ
dc.publisherPeerJ Inc.en_NZ
dc.relation.urihttps://doi.org/10.7717/peerj.2095
dc.rightsThis is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
dc.rights.accessrightsOpenAccessen_NZ
dc.subjectAxial spondyloarthritisen_NZ
dc.subjectMicrobiomeen_NZ
dc.subjectOral cavityen_NZ
dc.subjectPeriodontal diseaseen_NZ
dc.titleThe Oral Microbiome of Patients With Axial Spondyloarthritis Compared to Healthy Individualsen_NZ
dc.typeJournal Article
pubs.elements-id206846
pubs.organisational-data/AUT
pubs.organisational-data/AUT/Health & Environmental Science
pubs.organisational-data/AUT/Health & Environmental Science/Clinical Sciences
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