Leptin: A Pleitropic Factor in Physiology

Simple item page
aut.relation.endpage31
aut.relation.issue2en_NZ
aut.relation.journalJournal of Clinical and Health Sciencesen_NZ
aut.relation.startpage31
aut.relation.volume4en_NZ
aut.researcherAlshaikhli, Hisham
dc.contributor.authorAlmabhouh, FAen_NZ
dc.contributor.authorAhmad Muhammad, FIen_NZ
dc.contributor.authorIbrahim, Hen_NZ
dc.contributor.authorSingh, Hen_NZ
dc.date.accessioned2020-01-13T23:07:56Z
dc.date.available2020-01-13T23:07:56Z
dc.description.abstractLeptin, a 16 kDa protein and a product of the ob/ob gene, has a tertiary structure similar to that of a cytokine. It is primarily secreted by white adipose tissue and its levels in the blood correlate positively with percentage body fat. Leptin was first identified in 1994 as a major factor that regulated food intake and energy balance. Leptin in the circulation exists either as a free monomeric hormone or bound to its soluble receptor. Its serum levels usually range from 0.5 to 37.7 ng/ml in males and 2.0 to 45.2 ng/ml in females. The half-life of leptin is between 20 - 30 minutes and it is eliminated mainly by the kidneys. However, research over the last 25 years has revealed numerous other physiological roles for leptin, including roles in inflammation, immune function, neuro-endocrine function, bone metabolism, blood pressure regulation and sexual maturation. Most of these roles have been identified from studies on leptin deficient rodents. Apart from energy balance and sexual maturation, where its role is direct and obvious, its actions on the rest of the other systems are permissive. Actions of leptin are both centrally and peripherally mediated involving receptors that are widely distributed in the body. Six leptin receptor isoforms, belonging to the class 1 cytokine receptor family, have been identified. These receptors are products of the OBR gene. The cellular actions of leptin are mediated through any one of five different signalling pathways that include the JAK-STAT, PI3K, MAPK, AMPK, and the mTOR signalling pathways.en_NZ
dc.identifier.citationJournal Of Clinical And Health Sciences, 4(2), 31-57. doi:10.24191/jchs.v4i2.7551
dc.identifier.doi10.24191/jchs.v4i2.7551en_NZ
dc.identifier.issn0127-984Xen_NZ
dc.identifier.urihttps://hdl.handle.net/10292/13087
dc.publisherUiTM Press, Universiti Teknologi MARAen_NZ
dc.relation.urihttp://myjms.moe.gov.my/index.php/JCHS/article/view/7551
dc.rightsThis work is licensed under a Creative Commons Attribution 4.0 International License. The Copyright of this article is hereby assigned to JCHS effective upon acceptance by the Journal for publication. This assignment is for the exclusive right of reproduction and distribution of the article, including excerpts, translations, photographic reproduction, electronic formats (online and offline), or any other form of analogical reproduction. An author may make the article available on a personal website provided that the Journal’s name and date of publication are cited and the publisher is cited as the copyright owner.
dc.rights.accessrightsOpenAccessen_NZ
dc.subjectLeptin; Leptin receptors; Leptin signalling pathway; Leptin’s functions
dc.titleLeptin: A Pleitropic Factor in Physiologyen_NZ
dc.typeJournal Article
pubs.elements-id368332
pubs.organisational-data/AUT
pubs.organisational-data/AUT/Health & Environmental Science
pubs.organisational-data/AUT/Health & Environmental Science/Interprofessional Health
pubs.organisational-data/AUT/PBRF
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences/HI Interprofessional 2018 PBRF
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Published article-2019.pdf
Size:
543.37 KB
Format:
Adobe Portable Document Format
Description:
Journal article
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
AUT Grant of Licence for Tuwhera Aug 2018.pdf
Size:
276.29 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
School of Interprofessional Health Studies