Burden of Neurodegenerative Diseases in the Eastern Mediterranean Region, 1990-2016: Findings From the Global Burden of Disease 2016 Study

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aut.filerelease.date2020-04-30
aut.relation.journalEuropean Journal of Neurologyen_NZ
aut.researcherFeigin, Valery
dc.contributor.authorFereshtehnejad, S-Men_NZ
dc.contributor.authorVosoughi, Ken_NZ
dc.contributor.authorHeydarpour, Pen_NZ
dc.contributor.authorSepanlou, SGen_NZ
dc.contributor.authorFarzadfar, Fen_NZ
dc.contributor.authorTehrani-Banihashemi, Aen_NZ
dc.contributor.authorMalekzadeh, Ren_NZ
dc.contributor.authorSahraian, MAen_NZ
dc.contributor.authorVollset, SEen_NZ
dc.contributor.authorNaghavi, Men_NZ
dc.contributor.authorVos, Ten_NZ
dc.contributor.authorFeigin, Ven_NZ
dc.contributor.authorMurray, Cen_NZ
dc.contributor.authorMokdad, AHen_NZ
dc.contributor.authorMoradi-Lakeh, Men_NZ
dc.date.accessioned2019-04-30T02:21:20Z
dc.date.available2019-04-30T02:21:20Z
dc.date.copyright2019en_NZ
dc.date.issued2019en_NZ
dc.description.abstractBACKGROUND AND PURPOSE: The Eastern Mediterranean Region (EMR) is experiencing a demographic shift towards rapid ageing at a time of political unrest. We aimed to estimate the burden of neurodegenerative disorders, and its relationship with sociodemographic indicators (SDI) in the EMR countries from 1990 to 2016. METHODS: Using data from the Global Burden of Disease (GBD) 2016 study, we calculated country-specific trends for prevalence, mortality, disability-adjusted life-years (DALYs), years of life lost (YLLs), and years lived with disability (YLDs) for Alzheimer's disease/other dementias and Parkinson's disease in the EMR during 1990-2016. RESULTS: In EMR, age-standardized prevalence rate of Alzheimer's disease/other dementias and Parkinson's disease was estimated at 759.8 (642.9-899.9) and 87.1 (69.8-108.2) /100,000 in 2016, demonstrating 0.01% and 42.3% change from 1990, respectively. Neurodegenerative disorders contributed to 5.4% of total DALYs and 4.6% of total YLDs among the older EMR population aged 70 years or older in 2016. Age-standardized DALYs due to Parkinson's disease was strongly correlated with the SDI level (r=0.823, p-value<0.001). The YLD/DALY ratio of neurodegenerative diseases declined during this period in the low income EMR countries but not in high income ones. CONCLUSIONS: Our findings demonstrated an increasing trend in the burden of dementias and Parkinson's disease in most EMR countries between 1990 and 2016. With aging of the EMR populations, countries should target the modifiable risk factors of neurodegenerative diseases to control their increasing burden. This article is protected by copyright. All rights reserved.en_NZ
dc.identifier.citationEuropean Journal of Neurology, doi: 10.1111/ene.13972
dc.identifier.doi10.1111/ene.13972en_NZ
dc.identifier.issn1351-5101en_NZ
dc.identifier.issn1468-1331en_NZ
dc.identifier.urihttps://hdl.handle.net/10292/12474
dc.languageengen_NZ
dc.publisherWileyen_NZ
dc.relation.urihttps://onlinelibrary.wiley.com/doi/abs/10.1111/ene.13972
dc.rightsThis is the peer reviewed version of the following article: [European Journal of Neurology, doi: 10.1111/ene.13972], which has been published in final form at [10.1111/ene.13972]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
dc.rights.accessrightsOpenAccessen_NZ
dc.subjectAlzheimer's Diseaseen_NZ
dc.subjectDementiaen_NZ
dc.subjectEastern Mediterranean Region (EMR)en_NZ
dc.subjectGlobal Burden of Diseasesen_NZ
dc.subjectNeurodegenerative Diseasesen_NZ
dc.subjectParkinson's Diseaseen_NZ
dc.titleBurden of Neurodegenerative Diseases in the Eastern Mediterranean Region, 1990-2016: Findings From the Global Burden of Disease 2016 Studyen_NZ
dc.typeJournal Article
pubs.elements-id358765
pubs.organisational-data/AUT
pubs.organisational-data/AUT/Health & Environmental Science
pubs.organisational-data/AUT/Health & Environmental Science/Public Health & Psych Studies
pubs.organisational-data/AUT/PBRF
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences/HY Public Health & Psychosocial Studies 2018 PBRF
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