Population-level Risks of Alcohol Consumption by Amount, Geography, Age, Sex, and Year: A Systematic Analysis for the Global Burden of Disease Study 2020

aut.relation.endpage235
aut.relation.issue10347en_NZ
aut.relation.journalThe Lanceten_NZ
aut.relation.startpage185
aut.relation.volume400en_NZ
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dark.contributor.authorSchwebel, DCen_NZ
dark.contributor.authorSeidu, A-Aen_NZ
dark.contributor.authorSenthil Kumar, Nen_NZ
dark.contributor.authorSeyedAlinaghi, Sen_NZ
dark.contributor.authorSeylani, Aen_NZ
dark.contributor.authorSha, Fen_NZ
dark.contributor.authorShahin, Sen_NZ
dark.contributor.authorShahraki-Sanavi, Fen_NZ
dark.contributor.authorShahrokhi, Sen_NZ
dark.contributor.authorShaikh, MAen_NZ
dark.contributor.authorShaker, Een_NZ
dark.contributor.authorShakhmardanov, MZen_NZ
dark.contributor.authorShams-Beyranvand, Men_NZ
dark.contributor.authorSheikhbahaei, Sen_NZ
dark.contributor.authorSheikhi, RAen_NZ
dark.contributor.authorShetty, Aen_NZ
dark.contributor.authorShetty, JKen_NZ
dark.contributor.authorShiferaw, DSen_NZ
dark.contributor.authorShigematsu, Men_NZ
dark.contributor.authorShiri, Ren_NZ
dark.contributor.authorShirkoohi, Ren_NZ
dark.contributor.authorShivakumar, KMen_NZ
dark.contributor.authorShivarov, Ven_NZ
dark.contributor.authorShobeiri, Pen_NZ
dark.contributor.authorShrestha, Ren_NZ
dark.contributor.authorSidemo, NBen_NZ
dark.contributor.authorSigfusdottir, IDen_NZ
dark.contributor.authorSilva, DASen_NZ
dark.contributor.authorSilva, NTDen_NZ
dark.contributor.authorSingh, JAen_NZ
dark.contributor.authorSingh, Sen_NZ
dark.contributor.authorSkryabin, VYen_NZ
dark.contributor.authorSkryabina, AAen_NZ
dark.contributor.authorSleet, DAen_NZ
dark.contributor.authorSolmi, Men_NZ
dark.contributor.authorSOLOMON, Yen_NZ
dark.contributor.authorSong, Sen_NZ
dark.contributor.authorSong, Yen_NZ
dark.contributor.authorSorensen, RJDen_NZ
dark.contributor.authorSoshnikov, Sen_NZ
dark.contributor.authorSoyiri, INen_NZ
dark.contributor.authorStein, DJen_NZ
dark.contributor.authorSubba, SHen_NZ
dark.contributor.authorSzócska, Men_NZ
dark.contributor.authorTabarés-Seisdedos, Ren_NZ
dark.contributor.authorTabuchi, Ten_NZ
dark.contributor.authorTaheri, Men_NZ
dark.contributor.authorTan, K-Ken_NZ
dark.contributor.authorTareke, Men_NZ
dark.contributor.authorTarkang, EEen_NZ
dark.contributor.authorTemesgen, Gen_NZ
dark.contributor.authorTemesgen, WAen_NZ
dark.contributor.authorTemsah, M-Hen_NZ
dark.contributor.authorThankappan, KRen_NZ
dark.contributor.authorThapar, Ren_NZ
dark.contributor.authorThomas, NKen_NZ
dark.contributor.authorTiruneh, Cen_NZ
dark.contributor.authorTodorovic, Jen_NZ
dark.contributor.authorTorrado, Men_NZ
dark.contributor.authorTouvier, Men_NZ
dark.contributor.authorTovani-Palone, MRen_NZ
dark.contributor.authorTran, MTNen_NZ
dark.contributor.authorTrias-Llimós, Sen_NZ
dark.contributor.authorTripathy, JPen_NZ
dark.contributor.authorVakilian, Aen_NZ
dark.contributor.authorValizadeh, Ren_NZ
dark.contributor.authorVarmaghani, Men_NZ
dark.contributor.authorVarthya, SBen_NZ
dark.contributor.authorVasankari, TJen_NZ
dark.contributor.authorVos, Ten_NZ
dark.contributor.authorWagaye, Ben_NZ
dark.contributor.authorWaheed, Yen_NZ
dark.contributor.authorWalde, MTen_NZ
dark.contributor.authorWang, Cen_NZ
dark.contributor.authorWang, Yen_NZ
dark.contributor.authorWang, Y-Pen_NZ
dark.contributor.authorWesterman, Ren_NZ
dark.contributor.authorWickramasinghe, NDen_NZ
dark.contributor.authorWubetu, ADen_NZ
dark.contributor.authorXu, Sen_NZ
dark.contributor.authorYamagishi, Ken_NZ
dark.contributor.authorYang, Len_NZ
dark.contributor.authorYesera, GEEen_NZ
dark.contributor.authorYigit, Aen_NZ
dark.contributor.authorYiğit, Ven_NZ
dark.contributor.authorYimaw, AEAEen_NZ
dark.contributor.authorYon, DKen_NZ
dark.contributor.authorYonemoto, Nen_NZ
dark.contributor.authorYu, Cen_NZ
dark.contributor.authorZadey, Sen_NZ
dark.contributor.authorZahir, Men_NZ
dark.contributor.authorZare, Ien_NZ
dark.contributor.authorZastrozhin, MSen_NZ
dark.contributor.authorZastrozhina, Aen_NZ
dark.contributor.authorZhang, Z-Jen_NZ
dark.contributor.authorZhong, Cen_NZ
dark.contributor.authorZmaili, Men_NZ
dark.contributor.authorZuniga, YMHen_NZ
dark.contributor.authorGakidou, Een_NZ
dc.date.accessioned2022-08-08T23:17:06Z
dc.date.available2022-08-08T23:17:06Z
dc.date.copyright2022-07en_NZ
dc.date.issued2022-07en_NZ
dc.description.abstractBackground The health risks associated with moderate alcohol consumption continue to be debated. Small amounts of alcohol might lower the risk of some health outcomes but increase the risk of others, suggesting that the overall risk depends, in part, on background disease rates, which vary by region, age, sex, and year. Methods For this analysis, we constructed burden-weighted dose–response relative risk curves across 22 health outcomes to estimate the theoretical minimum risk exposure level (TMREL) and non-drinker equivalence (NDE), the consumption level at which the health risk is equivalent to that of a non-drinker, using disease rates from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2020 for 21 regions, including 204 countries and territories, by 5-year age group, sex, and year for individuals aged 15–95 years and older from 1990 to 2020. Based on the NDE, we quantified the population consuming harmful amounts of alcohol. Findings The burden-weighted relative risk curves for alcohol use varied by region and age. Among individuals aged 15–39 years in 2020, the TMREL varied between 0 (95% uncertainty interval 0–0) and 0·603 (0·400–1·00) standard drinks per day, and the NDE varied between 0·002 (0–0) and 1·75 (0·698–4·30) standard drinks per day. Among individuals aged 40 years and older, the burden-weighted relative risk curve was J-shaped for all regions, with a 2020 TMREL that ranged from 0·114 (0–0·403) to 1·87 (0·500–3·30) standard drinks per day and an NDE that ranged between 0·193 (0–0·900) and 6·94 (3·40–8·30) standard drinks per day. Among individuals consuming harmful amounts of alcohol in 2020, 59·1% (54·3–65·4) were aged 15–39 years and 76·9% (73·0–81·3) were male. Interpretation There is strong evidence to support recommendations on alcohol consumption varying by age and location. Stronger interventions, particularly those tailored towards younger individuals, are needed to reduce the substantial global health loss attributable to alcohol.
dc.identifier.citationThe Lancet, Volume 400, Issue 10347, 16–22 July 2022, pp. 185-235.
dc.identifier.doi10.1016/s0140-6736(22)00847-9en_NZ
dc.identifier.issn0140-6736en_NZ
dc.identifier.urihttps://hdl.handle.net/10292/15351
dc.languageenen_NZ
dc.publisherElsevier BVen_NZ
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S0140673622008479
dc.rights© 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.
dc.rights.accessrightsOpenAccessen_NZ
dc.titlePopulation-level Risks of Alcohol Consumption by Amount, Geography, Age, Sex, and Year: A Systematic Analysis for the Global Burden of Disease Study 2020en_NZ
dc.typeJournal Article
pubs.elements-id459402
pubs.organisational-data/AUT
pubs.organisational-data/AUT/Faculty of Health & Environmental Science
pubs.organisational-data/AUT/Faculty of Health & Environmental Science/National Institute Stroke & Applied Neurosciences
pubs.organisational-data/AUT/Faculty of Health & Environmental Science/National Institute Stroke & Applied Neurosciences/NISAN - Stroke
pubs.organisational-data/AUT/Faculty of Health & Environmental Science/School of Clinical Sciences
pubs.organisational-data/AUT/PBRF
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences/HY Public Health & Psychosocial Studies 2018 PBRF
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